Timing of Complete Revascularization in STEMI: Insights From the OPTION

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This editorial examines the findings of the OPTION–STEMI trial and their implications for the management of patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease.

While current guidelines recommend complete revascularization, the trial investigated whether non-culprit lesions should be treated immediately or in a staged procedure during the same hospital admission. The study found that immediate complete revascularization did not demonstrate non-inferiority compared with staged treatment.

Notably, patients with acute heart failure showed worse outcomes with immediate intervention, suggesting that a staged approach during the index hospitalization may be safer for higher-risk patients.

The editorial highlights the importance of individualized decision-making when determining the timing of multivessel PCI in STEMI patients.

# # # # # #

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Joon Ho Ahn and Youngkeun Ahn. Timing of Complete Revascularization in STEMI: Insights From the OPTION–STEMI Trial. CVIA. 2026. Vol. 11(1). DOI: 10.15212/CVIA.2026.0003

CVIA Journal