Category: News & Events

Right Ventricular Remodeling in Pulmonary Arterial Hypertension: From Adaptive Compensation to Maladaptive Failure

Announcing a new article publication for Cardiovascular Innovations and Applications Pulmonary arterial hypertension (PAH) comprises a group of progressive pulmonary circulatory diseases characterized by a persistent increase in pulmonary vascular resistance. In early-stage PAH, the right heart maintains systolic function via myocardial hypertrophy and structural remodeling.

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Night-Time Antihypertensive Dosing: A Personalized Strategy, Not a Universal Recommendation

Announcing a new article publication for Cardiovascular Innovations and Applications which challenges the idea that taking blood pressure medication at bedtime is beneficial for everyone.

In “Night-Time Antihypertensive Dosing: A Personalized Strategy, Not a Universal Recommendation,” researchers Nurul Nabilah Rohaimin and Rajan Rajabalaya from Universiti Brunei Darussalam examine clinical evidence showing that bedtime dosing may improve night-time blood pressure control but does not consistently reduce cardiovascular events.

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GPT-5.2 vs. DeepSeek-V3.2 in Simplifying Cardiac Magnetic Resonance Reports: A Prospective Real-World Study

Announcing a new article publication for Cardiovascular Innovations and Applications.  The aim of this study was to assess the feasibility of two large language models (LLMs), GPT-5.2 and DeepSeek-V3.2, for simplifying cardiac magnetic resonance (CMR) reports into participant-accessible language.

Participants undergoing CMR examinations were prospectively recruited. Original reports were randomly assigned in a 1:1 ratio to either GPT-5.2 or DeepSeek-V3.2. Predesigned prompts were used to guide the LLMs in generating simplified reports. Two customized structured Likert-scale questionnaires were developed to assess the performance and comprehensibility of the LLM-generated reports. The internal consistency and factor structure of these questionnaires were evaluated.

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Drug Development and Promising Therapeutic Targets for Coronary Artery Disease: Current Landscape and Future Prospects: CVIA State-of-the-Art Review

Announcing a new article publication for Cardiovascular Innovations and Applications. Coronary artery disease (CAD) remains the leading cause of death globally, despite the limited efficacy of current pharmacological therapies. The need for safer and more effective treatment strategies has never been more urgent. This review provides a contemporary overview of advances in CAD drug development. Novel lipid-lowering agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and angiopoietin-like protein 3 (ANGPTL3) inhibitors, anti-inflammatory therapies targeting interleukin pathways, and metabolic modulators have expanded the therapeutic landscape. Concurrently, precision medicine and drug repurposing approaches, informed by genomic profiling and biomarker-based stratification, are transforming the framework of CAD therapy. The integration of artificial intelligence into drug discovery further accelerates innovation.

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Genetic Insights Into the Association Between Sunburn Susceptibility and Thoracic Aortic Aneurysm Through Integrated Genomic and Transcriptomic Analyses

Announcing a new article publication for Cardiovascular Innovations and Applications. Ultraviolet B exposure may influence vascular homeostasis and extracellular matrix remodeling. Thoracic aortic aneurysm (TAA) is characterized by progressive aortic wall degeneration; however, its relationship with sunburn susceptibility remains unclear.

This study was aimed at investigating whether genetically predicted sunburn susceptibility might be associated with TAA risk, and to explore potential genomic and transcriptomic mechanisms.

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Obesity and Cardiovascular Diseases: CVIA State-of-the-Art Review

Obesity and Cardiovascular Diseases: CVIA State-of-the-Art ReviewAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Obesity, given its strong association with cardiovascular diseases (CVDs), is a major global public health issue attracting increasing attention. This comprehensive review systematically synthesizes clinical and basic research progress in elucidating the complex relationship between obesity and CVDs. The authors explore the epidemiology, pathophysiology, clinical manifestations, and management strategies for obesity-related CVDs.

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Aging and Cardiovascular Health

Aging and Cardiovascular HealthAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Aging is an inevitable biological process marked by progressive functional decline and elevated risk of cardiovascular diseases (CVDs). This review systematically examines the clinical mechanisms linking aging to cardiovascular pathology, focusing on molecular, cellular, and physiological changes that contribute to cardiovascular aging, which in turn increases the incidence of heart failure, atherosclerosis, atrial fibrillation, and other diseases. Key mechanisms include metabolic dysregulation, mitochondrial dysfunction, chronic inflammation, cellular senescence, immune disorders, and epigenetic changes.

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Role of Fruits and Vegetables in Reducing Cardiovascular Disease Risk: A Narrative Review

Fruit and vegetable intake as a strategy to lower cardiovascular risk.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Low consumption of fruits and vegetables (FV) is a major preventable contributor to cardiovascular disease (CVD). Insufficient FV intake has been estimated to account for nearly 3 million CVD deaths and more than 70 million disability-adjusted life years worldwide.

This review examines global patterns of FV intake; evidence linking FV consumption to cardiovascular outcomes; underlying biological mechanisms determined through in vitro and in vivo studies; serving size frameworks; current global recommendations; barriers to FV intake; and practical advice to increase FV intake.

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