Category: News & Events

GPT-5.2 vs. DeepSeek-V3.2 in Simplifying Cardiac Magnetic Resonance Reports: A Prospective Real-World Study

Announcing a new article publication for Cardiovascular Innovations and Applications.  The aim of this study was to assess the feasibility of two large language models (LLMs), GPT-5.2 and DeepSeek-V3.2, for simplifying cardiac magnetic resonance (CMR) reports into participant-accessible language.

Participants undergoing CMR examinations were prospectively recruited. Original reports were randomly assigned in a 1:1 ratio to either GPT-5.2 or DeepSeek-V3.2. Predesigned prompts were used to guide the LLMs in generating simplified reports. Two customized structured Likert-scale questionnaires were developed to assess the performance and comprehensibility of the LLM-generated reports. The internal consistency and factor structure of these questionnaires were evaluated.

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Drug Development and Promising Therapeutic Targets for Coronary Artery Disease: Current Landscape and Future Prospects: CVIA State-of-the-Art Review

Announcing a new article publication for Cardiovascular Innovations and Applications. Coronary artery disease (CAD) remains the leading cause of death globally, despite the limited efficacy of current pharmacological therapies. The need for safer and more effective treatment strategies has never been more urgent. This review provides a contemporary overview of advances in CAD drug development. Novel lipid-lowering agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and angiopoietin-like protein 3 (ANGPTL3) inhibitors, anti-inflammatory therapies targeting interleukin pathways, and metabolic modulators have expanded the therapeutic landscape. Concurrently, precision medicine and drug repurposing approaches, informed by genomic profiling and biomarker-based stratification, are transforming the framework of CAD therapy. The integration of artificial intelligence into drug discovery further accelerates innovation.

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Genetic Insights Into the Association Between Sunburn Susceptibility and Thoracic Aortic Aneurysm Through Integrated Genomic and Transcriptomic Analyses

Announcing a new article publication for Cardiovascular Innovations and Applications. Ultraviolet B exposure may influence vascular homeostasis and extracellular matrix remodeling. Thoracic aortic aneurysm (TAA) is characterized by progressive aortic wall degeneration; however, its relationship with sunburn susceptibility remains unclear.

This study was aimed at investigating whether genetically predicted sunburn susceptibility might be associated with TAA risk, and to explore potential genomic and transcriptomic mechanisms.

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Obesity and Cardiovascular Diseases: CVIA State-of-the-Art Review

Obesity and Cardiovascular Diseases: CVIA State-of-the-Art ReviewAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Obesity, given its strong association with cardiovascular diseases (CVDs), is a major global public health issue attracting increasing attention. This comprehensive review systematically synthesizes clinical and basic research progress in elucidating the complex relationship between obesity and CVDs. The authors explore the epidemiology, pathophysiology, clinical manifestations, and management strategies for obesity-related CVDs.

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Aging and Cardiovascular Health

Aging and Cardiovascular HealthAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Aging is an inevitable biological process marked by progressive functional decline and elevated risk of cardiovascular diseases (CVDs). This review systematically examines the clinical mechanisms linking aging to cardiovascular pathology, focusing on molecular, cellular, and physiological changes that contribute to cardiovascular aging, which in turn increases the incidence of heart failure, atherosclerosis, atrial fibrillation, and other diseases. Key mechanisms include metabolic dysregulation, mitochondrial dysfunction, chronic inflammation, cellular senescence, immune disorders, and epigenetic changes.

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Role of Fruits and Vegetables in Reducing Cardiovascular Disease Risk: A Narrative Review

Fruit and vegetable intake as a strategy to lower cardiovascular risk.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Low consumption of fruits and vegetables (FV) is a major preventable contributor to cardiovascular disease (CVD). Insufficient FV intake has been estimated to account for nearly 3 million CVD deaths and more than 70 million disability-adjusted life years worldwide.

This review examines global patterns of FV intake; evidence linking FV consumption to cardiovascular outcomes; underlying biological mechanisms determined through in vitro and in vivo studies; serving size frameworks; current global recommendations; barriers to FV intake; and practical advice to increase FV intake.

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Global Burden of Ischemic Cardio-Cerebrovascular Disease among Women from 1990 to 2021, with Projections to 2050

Global Burden of Ischemic Cardio-Cerebrovascular Disease among Women from 1990 to 2021, with Projections to 2050Announcing a new article publication for Cardiovascular Innovations and Applications journal.   The global burden, secular trends, and future projections of ischemic cardio-cerebrovascular disease (ICCVD), a composite indicator of ischemic heart disease (IHD) and ischemic stroke (IS), have not been specifically described in women. This study was aimed at estimating the global ICCVD burden from 1990 to 2021, and the projected burden from 2022 to 2050, in women.

Age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI), and corresponding average annual percentage change (AAPC) with 95% confidence intervals (CI) and associated P-values, were calculated for women at global, regional, and national levels according to data from Global Burden of Disease 2021. Age-specific patterns, DALYs attributable to risk factors, and DALY projections to 2050 were also examined.

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The Art of Timing: Recognizing Signs and Symptoms of Advanced Heart Failure to Guide Timely Referral to Advanced Heart Failure Specialists

Timely referral transforms advanced heart failure outcomesAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  This editorial highlights the critical importance of early recognition and referral of patients with advanced heart failure to specialist care.

The article provides frontline clinicians with a practical overview of disease progression, emphasizing the use of the “I NEED HELP” mnemonic as a simple screening tool to identify patients who may benefit from advanced therapies such as mechanical circulatory support, heart transplantation, and specialized multidisciplinary management.

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Socioeconomic, Lifestyle, and Clinical Factors Associated with Cardiovascular Events in the U.S. Cancer Population

Socioeconomic, Lifestyle, and Clinical FactorsAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Cardiovascular disease (CVD) is a leading cause of mortality among cancer survivors, yet the contributions of socioeconomic, lifestyle, and clinical factors to CVD remain unexplored.

This study was aimed at examining associations between these factors and prevalent CVD in adults with prior cancer and comparing them with those in a matched non-cancer cohort.

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