heart failure Archives - CVIA Journal

Tag: heart failure

Reimagining Heart Failure Care: The Essential Role of Early Palliative Integration

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Thie editorial highlights the growing evidence that type 2 inflammation may represent an important biological link between asthma and cardiovascular disease. The article examines how chronic inflammatory pathways driven by type 2 immune responses can contribute not only to respiratory symptoms but also to vascular dysfunction, atherosclerosis, and adverse cardiovascular outcomes. By exploring shared mechanisms across these conditions, the authors emphasize the need for a more integrated approach to patient care and suggest that targeting type 2 inflammation could offer new opportunities to improve outcomes for patients with both asthma and cardiovascular disease.

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Timing of Complete Revascularization in STEMI: Insights From the OPTION–STEMI Trial

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This editorial examines the findings of the OPTION–STEMI trial and their implications for the management of patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease.

While current guidelines recommend complete revascularization, the trial investigated whether non-culprit lesions should be treated immediately or in a staged procedure during the same hospital admission. The study found that immediate complete revascularization did not demonstrate non-inferiority compared with staged treatment.

Notably, patients with acute heart failure showed worse outcomes with immediate intervention, suggesting that a staged approach during the index hospitalization may be safer for higher-risk patients. (more…)

Transcatheter Tricuspid Valve Intervention Plus Optimized Medical Therapy Versus Optimized Medical Therapy Alone in Tricuspid Regurgitation: A Systematic Review and Meta-Analysis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Tricuspid regurgitation (TR) is common and associated with substantial morbidity and mortality. Although optimized medical therapy (OMT) can alleviate symptoms, it may be insufficient in severe cases, and surgical interventions carry considerable procedural risk, limiting their use; consequently, tricuspid transcatheter valve interventions (TTVIs) have emerged as a less invasive alternative. The authors of this article conducted a systematic search of PubMed, Scopus, and Web of Science to identify randomized clinical trials and observational studies comparing TTVI plus OMT versus OMT alone. The primary outcome was all-cause mortality, and secondary outcomes included heart failure (HF) hospitalization and a combined outcome of all-cause mortality and HF hospitalization.

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Guideline-Directed Medical Therapy in Heart Failure: The Need for Speed

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Heart failure (HF) represents one of the most pressing health challenges globally, affecting more than 64 million people worldwide. Despite therapeutic progress, HF remains a leading cause of hospitalization and mortality, particularly in patients with reduced ejection fraction (HFrEF), with annual costs, including hospitalizations, pharmacotherapy, and productivity losses, measured in the hundreds of billions of dollars. Readmissions remain common: roughly one in four patients is rehospitalized within 30 days in many healthcare (more…)

A Machine Learning Approach to Non-Exercise Prediction of Peak VO 2 in Advanced Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Peak oxygen consumption (VO₂), assessed via cardiopulmonary exercise testing (CPET), is central to heart transplant evaluation in advanced heart failure. However, many patients have limitations that prevent them from completing CPET. This study was aimed at developing machine learning 524 heart transplant candidates (ML) models to estimate peak VO₂ by using non-exercise clinical data who underwent comprehensive clinical, laboratory, echocardiographic, and hemodynamic assessment were retrospectively analyzed.

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Management of Malnutrition in Heart Failure to Optimize Guideline-Directed Medical Therapy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Malnutrition, therapeutic implementation, and clinical outcomes form an intertwined triad in heart failure management. Addressing malnutrition should not be considered an adjunctive measure but rather a critical component of precision cardiovascular care. Systematically integrating nutritional assessment and targeted intervention into HF treatment pathways offers a promising opportunity to improve therapy delivery, patient outcomes, and long-term prognosis. Moving forward, nutritional care deserves recognition as an essential pillar in the comprehensive management of heart failure.

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Nomogram-Based Prediction of Mortality after Cardiac Resynchronization Therapy in Patients with Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Heart failure (HF) with reduced ejection fraction (HFrEF; LVEF ≤ 35%) affects more than 64 million people globally. The 5-year all-cause mortality exceeds 40% among this population. CRT is a cornerstone treatment for patients with HFrEF with left bundle branch block, prolonged QRS complex duration (ventricular depolarization interval ≥ 150 ms on an electrocardiogram), and New York Heart Association (NYHA) class II–IV symptoms despite optimal medical therapy. However, many patients remain at high risk of mortality post-CRT, particularly those who develop new-onset atrial fibrillation (NOAF), which can disrupt resynchronization and worsen prognosis. Existing prognostic models often do not include NOAF and may lack precision.

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Association Between Malnutrition and Guideline-Directed Medical Therapy Utilization at Discharge in Hospitalized Patients with Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at identifying crucial gaps in guideline-directed medical therapy (GDMT) application among malnourished patients at Beijing Anzhen Hospital. Data from patients with heart failure (HF) admitted between January 1, 2018, and April 30, 2023, were analyzed. Malnutrition was assessed with Controlling Nutritional Status (CONUT) and Geriatric Nutritional Risk Index (GNRI) scores.

GDMT regimens were defined as follows. The triple-therapy regimen included β-blockers, renin-angiotensin system inhibitors (RASIs), and mineralocorticoid receptor antagonists (MRAs).

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Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM) is a specific type of cardiomyopathy that is independent of hypertension and coronary artery disease, and is closely associated with the high incidence and mortality of heart failure in people with diabetes.

DCM causes microvascular disease, myocardial metabolic disorder, and myocardial fibrosis, thereby leading to left ventricular remodeling, diastolic and/or systolic dysfunction, and eventually progressing to congestive heart failure.

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Adipokines Pathogenesis in Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Many studies have reported that obesity causes heart failure (HF) pathogenesis. The elevated circulating levels of angiopoietin-like protein 2 (ANGPTL2) observed in patients with HF suggest potential links among elevated ANGPTL2 levels, metabolic disturbances, and inflammation. C1q/TNF-related protein 3 and C1q/TNF-related protein 9 are diminished in patients with HF with reduced ejection fraction, in proportion to disease severity, and are associated with elevated morbidity and mortality. (more…)

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