Heart Failure Treatment in the Future

A Clinician’s Commentary on Heart Failure Treatment in the Future

A New Drug for Heart Failure

At long last a new drug for heart failure with a different mechanism of action has come on the scene to treat the heart failure patient. This new drug blocks the enzyme neprilysin, which is expressed in a variety of tissues and degrades several endogenous vasoactive (vasodilator) peptides. The inhibition of neprilysin increases the levels of these vasodilator peptides. When vasodilation occurs as a result of this new compound, bradykinin levels are not increased and thus cough and angioedema may not occur.

DOI: http://dx.doi.org/10.15212/CVIA.2015.0001


Updated: November 6, 2015 — 4:14 pm