Exploring Biomarkers for Early Diagnosis of Abdominal Aortic Aneurysms

Announcing a new article publication for Cardiovascular Innovations and Applications journal examines recent advances in circulating biomarkers for the early diagnosis and risk assessment of abdominal aortic aneurysm (AAA), a largely asymptomatic but potentially life-threatening vascular condition. The authors describe how pathological processes underlying AAA—such as inflammation, vascular smooth muscle cell dysfunction, extracellular matrix degradation, and thrombosis—release measurable molecular signals into the bloodstream, creating opportunities to improve detection beyond imaging alone.

The article synthesizes evidence for established clinical biomarkers, including D-dimer, C-reactive protein, B-type natriuretic peptide, and MMP-9, alongside emerging candidates identified through omics and machine-learning approaches, notably the VSMC-derived genes betacellulin (BTC) and KLF15. Highlighting a shift toward multi-biomarker panels and integrative analytics, the article underscores the potential of biomarker-guided strategies to enhance early diagnosis, refine risk stratification, and support more personalized management of AAA.

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Hongda Zhuang, Yong Chen and Khanjan B. Shah et al. Exploring Biomarkers for Early Diagnosis of Abdominal Aortic Aneurysms. CVIA. 2025. Vol. 10(1). DOI: 10.15212/CVIA.2025.0041

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