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Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults less than 45 Years of Age with Acute Coronary Syndrome

Announcing a new article publication for Cardiovascular Innovations and Applications journal. A non-invasive predictive model has not been established to identify the severity of coronary lesions in young adults with acute coronary syndrome (ACS). In this retrospective study, 1088 young adults (≤45 years of age) first diagnosed with ACS who underwent coronary angiography were enrolled and randomized 7:3 into training or testing datasets. To build the nomogram, the authors determined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operator and Random Forest algorithm. The predictive accuracy of the nomogram was assessed with calibration plots, and performance was assessed with the receiver operating characteristic curve, decision curve analysis and the clinical impact curve. Seven predictors were identified and integrated into the nomogram: age, hypertension, diabetes, body mass index, low-density lipoprotein cholesterol, mean platelet volume and C-reactive protein. Receiver operating characteristic analyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary artery disease in young patients with ACS in the training (area under the curve 0.683, 95% confidence interval [0.645–0.721]) and testing (area under the curve 0.670, 95% confidence interval [0.611–0.729]) datasets. The nomogram was also well-calibrated in both the training (P = 0.961) and testing (P = 0.302) datasets. Decision curve analysis and the clinical impact curve indicated the model’s good clinical utility. A simple and practical nomogram for predicting coronary artery disease severity in young adults ≤45 years of age with ACS was established and validated.

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. CVIA is indexed in the EMBASE, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ and Index Copernicus Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Article reference: Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults ≤45 Years of Age with Acute Coronary Syndrome, Zhang, Wenbin, Cardiovascular Innovations and Applications, 2022, https://doi.org/10.15212/CVIA.2022.0016

Termination of Recurrent Atrial Fibrillation by Superior Vena Cava Isolation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Paroxysmal atrial fibrillation can be triggered by non-pulmonary vein foci, such as the superior vena cava. The authors of this article report the case of a patient with a 6-year history of paroxysmal atrial fibrillation who received cryoballoon ablation in 2012 but relapsed. The patient then received cardiac radiofrequency ablation, which successfully isolated the left pulmonary vein and superior vena cava, but the arrhythmia relapsed again. The tachycardia was finally successfully terminated by ablation on the free wall without recurrence during a 2-year following up. Superior vena cava isolation may not require ablation isolation with a full circle way and can be accomplished by ablating several connection points between the superior vena cava and the right atrium.

Article reference: Termination of Recurrent Atrial Fibrillation by Superior Vena Cava Isolation: A Case Report, Yin, Dechun, Cardiovascular Innovations and Applications, 2022, https://doi.org/10.15212/CVIA.2022.0017

The Neutrophil/Lymphocyte Ratio is Associated with Different Stages of Development of Coronary Artery Disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Inflammation plays a role in coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and platelet/lymphocyte ratio (PLR) are blood parameters associated with inflammation. The authors of this article aimed to perform a systematic comparison and study the predictive values of these inflammatory parameters with respect to CAD stage. A total of 513 patients who had undergone coronary angiography (CAG) were retrospectively analyzed. Clinical status, lipid profiles, CAG scans and hematological parameters were collected. NLR, MLR and PLR were calculated. All patients were classified into a normal coronary group (n = 133), coronary atherosclerosis (CA) group (n = 149), chronic coronary syndrome (CCS) group (n = 175) or acute myocardial infarction (AMI) group (n = 56). NLR, MLR and PLR were compared among groups. NLR and MLR were higher in the CCS and AMI groups. PLR was higher in the AMI group. The AMI group had higher NLR, PLR and MLR than the CCS group. Logistic regression analysis revealed that NLR (OR:1.227, 95% CI: 1.016–1.482. P < 0.05) had a strong significant correlation with CAD. Area under the ROC curve of NLR was 0.580 (95% CI = 0.516–0.644) in predicting CCS and 0.727 (95% CI = 0.642–0.811) in predicting AMI. NLR may be associated with the occurrence and progression of CAD, and may serve as a marker of inflammation.

Article reference: The Neutrophil/Lymphocyte Ratio is Associated with Different Stages of Development of Coronary Artery Disease, Du, Jianlin, Cardiovascular Innovations and Applications, 2022, https://doi.org/10.15212/CVIA.2022.0018

Lowering of Blood Lipid Levels with a Combination of Pitavastatin and Ezetimibe in Patients with Coronary Heart Disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. According to the findings of randomized controlled trials, blood lipid levels in patients with coronary heart disease (CHD) can be significantly decreased through a combination of pitavastatin and ezetimibe; however, the effects and clinical applications of this treatment remain controversial. This article objectively assesses the efficacy and safety of pitavastatin and ezetimibe in lowering blood lipid levels.

Relevant studies were retrieved from electronic databases, including PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, VIP, and WanFang Data, from database inception to June 8, 2022. The levels of low-density lipoprotein cholesterol, total cholesterol, triglycerides, and high-density lipoprotein cholesterol in patients’ serum after treatment were the primary endpoint.

Nine randomized controlled trials (2586 patients) met the inclusion criteria. The meta-analysis indicated that pitavastatin plus ezetimibe resulted in significantly lower levels of LDL-C [standardized mean difference (SMD)=−0.86, 95% confidence interval (CI) (−1.15 to −0.58), P<0.01], TC [SMD=−0.84, 95% CI (−1.10 to −0.59), P<0.01], and TG [SMD=−0.59, 95% CI (−0.89 to −0.28), P<0.01] than pitavastatin alone.

Pitavastatin plus ezetimibe significantly decreased serum LDL-C, TC, and TG levels in patients with CHD.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0004

Article reference: Ruping Cai, Chen Chang and Xingjie Zhong et al. Lowering of Blood Lipid Levels with a Combination of Pitavastatin and Ezetimibe in Patients with Coronary Heart Disease: A Meta-Analysis. CVIA. Vol. 7(1). DOI: 10.15212/CVIA.2023.0004

Diagnosis of Coronary Artery Disease by Acoustic Analysis of Turbulent Murmur Caused by Coronary Artery Stenosis: A Single Center Study from China

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Intracoronary murmur results from turbulent flow due to coronary artery narrowing. This study evaluated the diagnostic performance of a method for acoustic analysis of turbulent murmur caused by coronary artery stenosis in coronary artery disease (CAD) in Chinese populations.

Patients admitted to the cardiovascular department of the Sixth Medical Center of the Chinese People’s Liberation Army General Hospital between September 2021 and June 2022 for elective coronary angiography were prospectively enrolled. A digital electronic stethoscope was used to record heart sounds before angiography. Quantitative coronary angiography (QCA) served as the “gold standard” for CAD diagnosis to evaluate the diagnostic performance of the acoustic analysis method for CAD.

A total of 452 patients had complete QCA and heart sound data. The final interpretation results of the acoustic analysis method indicated 310 disease cases and 142 normal results. Increasing the cut-off values of coronary artery diameter stenosis from 30% to 50%, 70%, and 90% increased the sensitivity and NPV of the acoustic analysis method; the sensitivity was 75.6%, 81.9%, 83.3%, and 85.7%, respectively; the NPV was 33.1%, 57.0%, 69.7%, and 88.0%, respectively; the specificity and PPV decreased (specificity of 75.8%, 70.4%, 51.0%, and 37.5%, respectively; PPV of 95.2%, 89.0%, 69.4%, and 32.9%, respectively); and the AUC values were 0.757, 0.762, 0.672, and 0.616, respectively. The sensitivity of the acoustic analysis method for one-vessel disease was 86.6% when the cut-off value was 50%. The sensitivity for identifying left anterior descending coronary artery lesions was best, at 90.7%. The sensitivity for identifying isolated coronary artery branch lesions was 66.7%, whereas the sensitivity for identifying three-vessel disease in multi-vessel coronary artery lesions was better, at 82.9%.

Acoustic analysis of turbulent murmur caused by coronary artery stenosis for diagnosis of CAD may have favorable performance in the Chinese population. This method has good performance in CAD diagnosis with a cut-off coronary artery diameter for stenosis of 50%.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2022.0023

Article reference: Pan-Guo Zhao, Yi-Xiong Huang and Li-Ping Xiao et al. Diagnosis of Coronary Artery Disease by Acoustic Analysis of Turbulent Murmur Caused by Coronary Artery Stenosis: A Single Center Study from China. CVIA. Vol. 7(1). DOI: 10.15212/CVIA.2022.0023

Jamie B. Conti, MD, FACC, FHRS Appointed Co-Editor-in-Chief, Cardiovascular Innovations and Applications

On behalf of the journal, Compuscript is pleased to announce the appointment of Jamie B. Conti, MD, FACC, FHRS, as Co-Editor-in-Chief of Cardiovascular Innovations and Applications (CVIA) succeeding the late C. Richard Conti, MD, MACC, Dr HC, FCP(SA), FESC, FAHA. The appointment is effective immediately. Dr Conti is no stranger to CVIA having served as an Associate Editor for the journal since its launch in 2015.

A Professor of Medicine and serving as the University of Florida (UF) Department of Medicine Chair, Dr Conti earned her undergraduate degree from Harvard University and is a 1987 graduate of the UF College of Medicine. She completed her medical residency at Emory University and fellowship training in cardiology and clinical cardiac electrophysiology at UF. She joined UF’s faculty in 1994 as an Assistant Professor of Medicine and has held numerous leadership roles since then, including serving 10 years as the Chief of Cardiovascular Medicine. Dr Conti is board certified in Cardiovascular Medicine. In 1999, Dr Conti received the prestigious American College of Cardiology Proctor Harvey Teaching Award. In addition to her roles within UF, she has held leadership positions in the American College of Cardiology, the Heart Rhythm Society and the American Heart Association. Dr Conti’s research focuses on intracardiac device implantation, pregnancy and arrhythmias, and psychological manifestations of ICD implantation.

Commenting on the appointment, Dr Conti said:

“My vision is to make CVIA a preeminent journal in the cardiovascular field”. “We hope this journal will become a trusted source of accurate and reproducible data in the cardiovascular field, raising the standard of research, and accelerating the process of diagnostic innovation and application of technology in cardiovascular disease.”

For further information on CVIA please see http://www.cvia-journal.org/

Submissions may be made using ScholarOne Manuscripts https://mc04.manuscriptcentral.com/cvia-journal There are no author submission or article processing fees.

Follow CVIA on Twitter @CVIA_Journal; or Facebook https://www.facebook.com/cvia.journal/

Editorial Board Retirements Acknowledgement

We would like to thank the following people who are retiring from our editorial board for all their help and support for CVIA over the last number of years.

Associate Editors

Juan M. Aranda, Jr, MD, FACC, Professor of Medicine, Director of Heart Transplant Program, Director of Heart Failure Fellowship Program, University of Florida, Gainesville, FL, USA

Jian Zhang, MD, Professor of Medicine, State Key Laboratory of Cardiovascular Disease, Heart Failure Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

Shenghua Zhou, MD, Director, Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China

Editorial Board

Alan B. Miller, Professor, Department of Medicine, University of Florida, USA

An Pan, Professor, Assistant Dean, Huazhong University of Science and Technology, China

Anthony DeMaria, Professor of Medicine, Judith and Jack White Chair in Cardiology, University of California San Diego, USA

Antonio Colombo, Director, Cardiac Cath Lab and Interventional Cardiology Unit, EMO GVM Centro Cuore, Columbus and San Raffaele Hospital, Milan, Italy

Bertram Pitt, Professor of Internal Medicine, University of Michigan, USA

Bo Yu, Director of Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, China

Calvin Choi, Assistant Professor of Medicine, University of Florida, USA

Carl J. Pepine, Professor Emeritus, University of Florida, USA

Carsten M. Schmalfuss, Assistant Professor, University of Florida, USA

Changsheng Ma, Director, Cardiology Department of Beijing Anzhen Hospital, Cardiology, Beijing, China

Christopher Kramer, Ruth C. Heede Professorship in Cardiology; Director, Cardiovascular Imaging Center, University of Virginia, USA

Chuanyu Gao, Professor, Vice Dean of CVD, Henan Provincial People’s Hospital, China

Clive Rosendorff, Professor, Department of Medicine, Icahn School of Medicine, USA

Dali Fan, Health Science Clinical Professor, University of California, Davis, USA

Daowen Wang, Professor, Director of Depart of CVD, Huazhong University, China

David E. Winchester, Assistant Professor, Division of Cardiovascular Medicine, University of Florida, USA

David R. Holmes, Mayo Clinic, USA

Deepak L. Bhatt, Professor, Harvard Medical School, Brigham and Women’s Hospital, Boston MA, USA

Dobrin Vasilev, National Heart Hospital, Bulgaria

Dominick Angiolillo, Professor, Department of Medicine, Division of Cardiology, University of Florida, USA

Dong Zhao, Professor, Deputy Director of Beijing Institute of Heart, Lung & Blood Vessel Diseases, Beijing Anzhen Hospital, China

Dudley Pennell, Professor of Cardiology, Royal Brompton Hospital, UK

Edgardo Escobar, University of Chile, Chile

Eileen Handberg, Research Professor of Medicine, University of Florida, USA

Ezra Amsterdam, University of California Davis, USA

Faisal Latif, Assistant Professor of Medicine, University of Oklahoma, USA

Felicita Andreotti, Professor, Cardiovascular Medicine, Institute of Cardiology, Catholic University, Italy

Filippo Crea, Professor, Institute of Cardiology, Catholic University, Italy

Freek W.A. Verheugt, Professor of Cardiology, Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

George Abela, Professor of Medicine, Chief, Division of Cardiology, Michigan State University, USA

George W. Vetrovec, Emeritus Professor of Medicine, VCU Medical Center, USA

Gerald V. Naccarelli, Bernard Trabin Chair in Cardiology, Professor of Medicine, Chief of the Division of Cardiology, Penn State University, USA

Gianluca Rigatelli, Rovigo Hospital, Italy

Hector O. Ventura, Oschner Medical Center, USA

Hong Jiang, Professor, Director of Department of CVD, Renmin Hospital of Wuhan University, China

Hongsheng Guo, Sacred Heart Medical Center, USA

Hongwei Li, Professor, Beijing Friendship Hospital, China

Hugh Calkins, The Johns Hopkins Hospital, USA

Ileana L. Piña, Professor, Department of Medicine, Department of Epidemiology & Population Health, Montefiore Medical Center, USA

Jacqueline Noonan, Professor Emeritus, University of Kentucky Medical Center, USA

James A. Hill, University of Florida, USA

James Goldstein, William Beaumont Hospital, USA

Jan Daniel Marx, Director of Cardiology Department, Cardiologist, Bloemfontein, South Africa

Jawahar Mehta, Stebbins Chair and Professor of Medicine, University of Arkansas, USA

Jeroen J. Bax, Professor of Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

Jianan Li, Professor, Chairman of the Center of Rehabilitation Medicine, Jiangsu Province Hospital, China

Jianjun Jiang, Director of Department of CVD, Taizhou Hospital of Zhejiang Province, China

Jie Du, Professor, Vice Director of the Cardiovascular Research Institute of Beijing, Beijing Anzhen Hospital, China

Jing Huang, Professor, Director of Interventional Ultrasound Research Center, Chongqing Medical University, China

John Camm, Professor of Clinical Cardiology, University of London, UK

John Douglas, Professor of Medicine, Emory University Hospital, USA

John F. Beltrame, Professor of Medicine, Michelle Chair, University of Adelaide, Australia

John W. Hirshfeld, Professor of Medicine, Hospital of the University of Pennsylvania, USA

John W. Petersen, Assistant Professor of Medicine, Division of Cardiovascular Medicine, University of Florida, USA

Juan Carlos Kaski, Professor of Cardiovascular Science, University of London, UK

Juan Vilaro, Clinical Assistant, Professor of Medicine, Department of Cardiovascular Medicine, UF Health, FL, USA

Keiichi Fukuda, Professor, Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University, Japan

Lars Wallentin, Senior Professor, Cardiology, Uppsala University, Sweden

Laurence S. Sperling, Emory University School of Medicine, USA

Liming Li, Professor, Dean of Preventive Medicine Academy, China Academy of Medical Science, China

Linong Ji, Professor of Medicine, Director of Department of Endocrinology and Metabolism, Peking University People’s Hospital, China

Lixin Jiang, Professor, Vice Director of Department of CVD, Fu Wai Hospital, China

Lizhong Sun, Professor, Director of Department of Cardiothoracic Surgery, Beijing Anzhen Hospital, China

Luigi Biasucci, Associate Professor of Cardiology, Catholic University, Italy

Magdi Yacoub, Professor of Cardiothoracic Surgery, Imperial College London, UK

Marvin Eng, Henry Ford Hospital, USA

Matthew S. McKillop, Assistant Professor, Division of Cardiovascular Medicine, University of Florida, USA

Meilin Liu, Professor, Director of Department of Elderly CVD, Peking University First Hospital, China

Michael Nguyen, Assistant Professor, Director of Clinical Trials and Research, University of Western Australia, Australia

Patricia A. Pellikka, Director, Echocardiography Laboratory, Mayo Clinic, USA

Patrick T. O’Gara, Professor, Director, Clinical Cardiology, Executive Medical Director, Shapiro Cardiovascular Center, Brigham & Women’s Hospital, USA

Peter A. McCullough, Baylor University Medical Center, USA

Peter Ong, Robert Bosch Hospital, Germany

Petros Nihoyannopoulos, Professor of Cardiology, Imperial College London, UK

Ping Ye, Professor, Director of Department of CVD, Chinese PLA General Hospital, China

Qing Wang, Professor, Dean of Life Sciences, Huazhong University of Science and Technology, China

Renu Virmani, Clinical Professor, Department of Pathology, President, CVPath Institute, USA

Richard Schofield, Professor of Medicine, Division of Cardiovascular Medicine, University of Florida, USA

Roger A. Winkle, Silicon Valley Cardiology, USA

Roger W. Roberts, Adjunct Professor of Medicine, Wichita, KS, USA

Shuiping Zhao, Professor, Director of Department of CVD, The Second Xiangya Hospital, China

Shulin Wu, Professor, Vice Dean, Guangdong General Hospital, China

Sidney C. Smith, Professor of Medicine, University of NC, USA

Spencer King, Emory University, USA

Stephen D. Wiviott, Associate Professor, Brigham & Womens Hospital, USA

Subbu Venkatraman, Professor, Northwestern Nanomedicine Institute, Singapore

Suzanne Oparil, Professor of Medicine, Director, Vascular Biology and Hypertension Program, University of Alabama, USA

Thomas A. Burkart, Associate Professor of Medicine, University of Florida, USA

Udo Sechtem, Professor, Robert Bosch Hospital, Germany

William G. Hundley, Professor Internal Medicine-Cardiology, Wake Forest Baptist Medical Center, USA

William G. Stevenson, Professor, Vanderbilt Medical Center, Nashville, TN, USA

William M. Miles, Professor of Medicine, University of Florida, USA

Win-Kuang Shen, Mayo Clinic, USA

Xiaohui Guo, Peking University First Hospital, China

Yaling Han, Professor, Director of CVD Research Center, The General Hospital of Shenyang Military, China

Yean Leng Lim, Professor, Director, Raffles Heart Center, Singapore

Yihan Chen, Professor, Vice Dean of Medical College, Tongji University, China

Yong Huo, Professor, Department of Cardiology, Peking University First Hospital, China

Yong Li, Professor, Director of CVD Research Center, Huashan Hospital, Fudan University, China

Yongjun Wang, Professor, Director of Neuroscience Center, Beijing Tiantan Hospital, China

Yuhua Liao, Professor, Union Hospital, Tongji Medical College ,Huazhong University of Science and Technology, China

Zhe Zheng, Professor, Assistant Dean, Fu Wai Hospital, China

Zuyi Yuan, Professor, Director of Department of CVD, Xi’an Jiaotong University Health Center, China

Without their involvement and advice, the journal would not have become the success it has. Their contributions have been invaluable.

Jianzeng Dong, MD, PHD

Editor in Chief, CVIA

CVIA Volume 6 Issue 4 published

The journal Cardiovascular Innovations and Applications (CVIA) has just published the final issue of Volume 6 Issue 4 which includes several important papers by leading cardiologists in China, the United States and Turkey. It also includes an In Memoriam paper in tribute to the life and work of Dr C.R. Conti, one of the Founding Editors of the journal who sadly passed away earlier this year.

PAPERS IN THE ISSUE ARE AS FOLLOWS:

Jianzeng Dong and Dayi Hu
In Memoriam: C. Richard Conti, MD (1934 – 2022), Founding Editor-in-Chief of Cardiovascular Innovations and Applications

Lutfu Askin and Okan Tanriverdi
The Clinical Value of Syntax Scores in Predicting Coronary Artery Disease Outcomes

Yu Geng, Yintang Wang, Lianfeng Liu, Guobin Miao, Ou Zhang, Yajun Xue and Ping Zhang
Staged Revascularization for Chronic Total Occlusion in the Non-IRA in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: An Updated Systematic Review and Meta-analysis

Zhengyang Hao and Yanzhou Zhang
Dapagliflozin in Heart Failure with Reduced Ejection Fraction: A Real-World Study

Boda Zhou, Qizhong Li, Yajun Xue, Lihao Huang, Jie Zhou, Ou Zhang, Ping Zhang and Gangtie Zheng
A Novel Robotic Control System Mimics Doctor’s Operation to Assist Percutaneous Coronary Intervention

Mahesh Chandrasekhar, David Zhao and Karl Richardson
Comparison of Post-Procedural and 30-day Post-Implantation Transcatheter Aortic Valve Replacement Gradients with and without pre-implantation Balloon Valvuloplasty: A Real-World Analysis of Early Results using a Novel Balloon Expandable Transcatheter Aortic Valve

Qiong Wu, Jianfeng Qian, Qingjun Liu and Jianhua Fan
A Case of Premature Ventricular Complexes from the Proximal Left Bundle Branch Successfully Ablated from the Right Coronary Cusp

Ruoyi Guo, Gang Li, and Yifang Guo
Hypertensive-Like Reaction: A Definition for Normotensive Individuals with Symptoms Associated with Elevated Blood Pressure

CVIA Volume 6 Issue 3 Published

The journal Cardiovascular Innovations and Applications (CVIA) has just published the third issue of Volume 6. This issue brings together important research from authors in China and the United States.

Papers in the issue are as follows.

REVIEW

Guoshuang Feng, Guoyou Qin, Tao Zhang, Zheng Chen and Yang Zhao

Common Statistical Methods and Reporting of Results in Medical Research

(DOI 10.15212/CVIA.2022.0001)

ORIGINAL ARTICLE

Rong-Xue Xiao, Xu Wang, Jun-Qing Gao and Zong-Jun Liu

A Case Summary of the Application of a Drug-Eluting Stent Combined with a Drug-Coated Balloon

in Left Main Coronary Artery Disease (DOI 10.15212/CVIA.2021.0027)

RESEARCH PAPERS

Hui Yang, Pu Zou, Yuhu He, Lingzhi Huang, Xinmin Zhou, Liming Liu, Zhenjiang Liu and Shenghua Zhou

Risk Factors for Prognosis after the Maze IV Procedure in Patients with Atrial Fibrillation

Undergoing Valve Surgery (DOI 10.15212/CVIA.2021.0026)

Yang Liu, Xunxun Feng, Jiaqi Yang, Tienan Sun, Guangyao Zhai, Qianyun Guo and Yujie Zhou

Prognostic Significance of HbA_1c Level in Asian Patients with Prediabetes and Coronary Artery Disease (DOI 10.15212/CVIA.2021.0029)

Xiaoling Ji, Shuqi Jin, Yuxia Wang, Yumiao Chen and Jing Zhang

Visfatin and 25-Hydroxyvitamin D3 Levels Affect Coronary Collateral Circulation Development in Patients with Chronic Coronary Total Occlusion (DOI 10.15212/CVIA.2021.0032)

Jia-Min Li, Wen-Yuan Ding, Fei Zheng, Yan-ying Jia, Li-Li Wang, Xin-Yi Wei, Ming-Ming Zhang, Cuihua Li and Guo-Hua Li

Effects of Tirofiban and Nicorandil on Effective Reperfusion and the Levels of IL-4 and sICAM-1 After PCI for Chronic Coronary Total Occlusion (DOI 10.15212/CVIA.2021.0033)

Boda Zhou, Yajun Xue, Jie Zhou, Shenjie Sun, Tingting Lv, Ou Zhang, Yu Geng, Guobin Miao and Ping Zhang

Fasting Blood Glucose but not TMAO is Associated with In-Stent Restenosis in Patients with Acute

Coronary Syndrome (DOI 10.15212/CVIA.2021.0034)

CASE REPORT

Oliver Abela, Michael Schoeller, Parker Williams, Charles Lambert and Marc Bloom

Valve-in-Valve Transcatheter Aortic Valve Replacement in a High-Risk Patient with a Biocor Bioprosthesis and a Flail Prosthetic Valve Leaflet (DOI 10.15212/CVIA.2021.0031)

Richard Conti, MD, MACC, Dr HC, FCP(SA), FESC, FAHA

Feb 24, 2022

It is with great sadness that we announce the passing of esteemed cardiovascular researcher and educator, and Editor in Chief of Cardiovascular Innovations and Applications, C. Richard Conti. Dr Conti has been deeply instrumental to the development of the journal since its launch in 2015; the Editorial Board and Publisher will greatly miss his enthusiasm and passion for cardiology research.

We extend our condolences to Dr Conti’s family, in particular to Editorial Board Member, Dr Jamie B. Conti, and to his friends and colleagues.

Dr. Conti’s honored career as a physician, researcher, teacher, administrator and prolific writer and editor spanned six decades. Born in Allentown, Pennsylvania in 1934, Dr. Conti grew up in Bethlehem and graduated from Lehigh University in 1956 and from the Johns Hopkins School of Medicine in 1960 as a member of the Alpha Omega Alpha Honor Society. He trained in internal medicine with the Osler Medical Service of The Johns Hopkins Hospital and completed a fellowship in cardiology at the same institution. Dr. Conti’s training was interrupted for two years when he served in the U.S. Army from 1962 to 1964. He was named chief resident of the Osler Medical Service in 1967, and in 1968, he joined the Johns Hopkins faculty as an assistant professor of medicine, rising to associate professor and medical director of the cardiac catherization laboratory before leaving for the University of Florida.

He served as president of the American College of Cardiology from 1989 to 1990, and was an elected member of the American Clinical and Climatological Association, the Association of University Cardiologists, and the Association of Professors in Cardiology. In 1991, Dr. Conti received an honorary fellowship from the College of Medicine of South Africa (FCP-SA), and in 1996, he was elected to the Johns Hopkins University Society of Scholars. He was awarded the Gifted Teacher Award from the Florida Chapter of the American College of Cardiology in 1999, and from the American College of Cardiology in 2002. In June 2000, he received a “Docteur Honoris Causa” from the University of Marseilles, and in 2004, he was named China Honorary Chair of the Great Wall International Congress of Cardiology (GW-ICC), Beijing.

Dr. Conti had a passion for teaching, and he shared his knowledge through his work as a writer and editor. He served as editor-in-chief for Educational Program Highlights of the American College of Cardiology for 14 years, for Clinical Cardiology for 13 years and for American College of Cardiology Extended Learning for 10 years. He was an editorial board member for the American Journal of Cardiology, the Journal of the American College of Cardiology, the European Heart Journal and numerous others. He authored or co-authored more than 700 scientific papers, book chapters and abstracts, and edited six books and wrote two.

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