Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and diabetes risk in Chinese Han people
Cong Ma Bingxiang Yu Qiang Zeng
Health Management Institute of Chinese PLA General Hospital
Objectives: Diabetes is a multiple factor disease which was influenced by gene, environment, and lifestyle. Several studies confirmed that the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is associated with diabetes. However, the evidence remains inconclusive. Whether lifestyle affects the development of diabetes in different genotype groups have not been clarified, either. We sought to identify associations between ALDH2 rs671 polymorphism, lifestyles, and diabetes in Chinese Han people.
Methods: The subjects were adult Chinese Han people who received heath examination in the period from December 2015 to December 2016. Detection of the ALDH2 r671 polymorphism was determined by polymerase chain reaction. Lifestyle data were collected using self-administered questionnaires. Basiccharacteristicsand fasting venous blood sample were collected at baseline.
Results: 3519 subjects were eligible for participation. The frequencies of the ALDH2 rs671 genotype were 67.1% (GG), 30.2%(GL), 2.7%(LL), respectively. ALDH2 rs671 polymorphism was significantly associated with diabetic risk (GG vs. GL+LL: OR=1.33, 95% CI=1.07-1.66, P=0.01). In different groups, the association between lifestyle and diabetic risk were also significant difference. In the homozygous group, smoking and drinking were significantly increased the risk of diabetes rather than in heterozygous group(smoking:OR=1.53, 95% CI:1.31–1.79, p<0.001; drinking:OR=1.62, 95% CI:1.33–1.99, p<0.001). Pickled foods intake was significantly increased the risk of diabetes in homozygous group (OR=1.71, 95% CI: 1.15–2.54,P=0.008). Fried foods intake was significantly decreased the risk of diabetes in heterozygous group(OR=0.45, 95% CI: 0.28–0.70,P=0.001).
Conclusions: Our study suggested that ALDH2 rs671 polymorphism might be able to be used as a predictor for the risk of diabetes in Chinese Han people. Smoking, drinking and pickled foods intake were risk factors for diabetes in the homozygous group, while fried food intake is a protective factor in heterozygous group.