Association between homocysteine levels and calcific aortic valve disease: a meta-analysis
Qingchun Zeng Guandi Wu Jiayi Xian Jun Li Die Zhu Ruxia Liang Xi Yang Jiaying Li Ying Huang Yan Tu Dingli Xu
Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Objectives: Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). This study aims to investigate the association between Hcy levels in patients with CAVD by conducting a meta-analysis.
Methods: We conducted a systematic search in the database of PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials and Chinese Biomedical Literature Database (CBM) up to March 2017. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Pooled results were reported as weighted mean difference (WMD) and the corresponding 95% confidence intervals (95% CI).
Results: Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared wih controls (pooled WMD: 2.98, 95%CI: 1.59 to 4.38). Significantly higher Hcy levels were found both in mild-to-moderate CAVD patients (WMD: 0.62, 95% CI: 0.11 to 1.13) and severe CAVD patients (WMD: 3.15, 95% CI: 2.44 to 3.86) than in controls. In addition, Hcy levels were significantly higher in severe CAVD patients than in mild-to-moderate CAVD patients (WMD: 3.23, 95% CI: 1.14 to 5.32).
Conclusions: The present meta-analysis revealed that Hcy levels significantly increased in CAVD patients with the progression of the disease.