Tag: microRNAs

MicroRNAs Have an Immunomodulatory Role in Diabetes Mellitus and Diabetic Cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, myocardial hypertrophy, and fibrosis. Factors such as hyperglycemia, metabolic disorders, microangiopathy, inflammation, oxidative stress, and insulin resistance have been found to play important roles in DCM pathophysiology.

Recent research has shown that miRNAs are involved in processes such as myocardial cell proliferation, differentiation, and metastasis, and promote the progression of DCM. Despite these insights, the regulatory effects of miRNAs on immune function in DCM remain inadequately explored.

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Serum Extracellular Vesicle-derived microRNA Profiles in Patients with ST-segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

extracellular-vesicle-micrornas-ami-diagnostic-biomarkers.jpgAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.

Peripheral blood samples were collected from three patients with AMI and three healthy individuals, and serum EV total RNA was extracted. The miRNA differential expression profiles of serum EVs were obtained through next-generation sequencing combined with bioinformatics analysis.

In patients with AMI, compared with controls without AMI, 15 differentially expressed miRNAs (more…)

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