Tag: ion channels

Alternative RNA Splicing in Cardiac Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function.

In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long non-coding RNAs, can contribute to the development of cardiovascular diseases. In addition, multiple hereditary heart-related diseases are caused by mutations associated with AS.

(more…)

Loading

Identification of Arrhythmia-Associated Gene Mutations in Chinese Patients with Primary Electrical Disorders or Sudden Cardiac Death

Identification-of-Arrhythmia-Associated-Gene-MutationAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Sudden cardiac death (SCD), unexpected death based on sudden cardiac ejection cessation, accounts for 15–20% of unnatural deaths in developed countries. Primary electrical disorders (PEDs), a group of cardiac rhythm abnormalities without detectable structural heart disease, are a major cause of SCD in people younger than 35 years of age. (more…)

Loading