Diabetes mellitus Archives

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, myocardial hypertrophy, and fibrosis. Factors such as hyperglycemia, metabolic disorders, microangiopathy, inflammation, oxidative stress, and insulin resistance have been found to play important roles in DCM pathophysiology.

Recent research has shown that miRNAs are involved in processes such as myocardial cell proliferation, differentiation, and metastasis, and promote the progression of DCM. Despite these insights, the regulatory effects of miRNAs on immune function in DCM remain inadequately explored.

(more…)

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from impaired insulin secretion or insulin resistance. Diabetes poses a major global health concern, because of its increasing prevalence and substantial morbidity and mortality. This review explores the relationships between altered fatty acid metabolism and microcirculatory impairments in diabetes. Dysregulation of fatty acid metabolism in diabetes leads to changes in fatty acid profiles, abnormal lipid accumulation, and increased oxidative stress. These changes contribute to microvascular dysfunction through mechanisms such as endothelial dysfunction, impaired nitric oxide availability, inflammation, and oxidative damage. Understanding this intricate interplay is essential for identifying novel therapeutic strategies to alleviate vascular complications in diabetes. By targeting specific pathways involved in fatty acid metabolism and microvascular dysfunction, interventions can be developed to improve patient outcomes. This article is aimed at contributing to future research and the development of effective strategies for preventing and managing diabetes-associated microcirculatory impairments, to ultimately enhance the quality of life for people living with diabetes.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0076

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Jianjun Wu, Youqi Zhang and Liu Ji et al. Associations Among Microvascular Dysfunction, Fatty Acid Metabolism, and Diabetes. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0076