CVIA Journal

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  The ubiquitin-proteasome system is a fundamental cellular process increasingly considered for diagnostic and therapeutic strategies. Current research on Casitas B-lineage lymphoma (CBL) proteins primarily focuses on understanding its precise roles in the development of different diseases and exploring the feasibility of targeting CBL as a potential therapeutic target by inhibiting or enhancing its function.

On the one hand, blocking the interaction between Casitas B-lineage lymphoma and E2 by small molecules targeting the RING domain of CBL may enhance the activity of CBL-b and c-Cbl, potentially offering therapeutic value in cancer treatment. On the other hand, targeted deletion of the Casitas B-lineage lymphoma gene in specific cells can suppress CBL protein expression levels.

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