cardiovascular diseases Archives

Role of the E3 Ubiquitin Ligase CBL Family in Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The ubiquitin-proteasome system is a fundamental cellular process increasingly considered for diagnostic and therapeutic strategies. Current research on Casitas B-lineage lymphoma (CBL) proteins primarily focuses on understanding its precise roles in the development of different diseases and exploring the feasibility of targeting CBL as a potential therapeutic target by inhibiting or enhancing its function.

On the one hand, blocking the interaction between Casitas B-lineage lymphoma and E2 by small molecules targeting the RING domain of CBL may enhance the activity of CBL-b and c-Cbl, potentially offering therapeutic value in cancer treatment. On the other hand, targeted deletion of the Casitas B-lineage lymphoma gene in specific cells can suppress CBL protein expression levels.

(more…)

Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs.

To determine whether PECAM-1 and CVDs are causally associated, the authors of this article conducted a two-sample Mendelian randomization (TSMR) study.

(more…)

Research Progress in Heart Rate Variability Applications in Exercise Rehabilitation for Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Heart rate variability (HRV) is an important marker for assessing the balance of the autonomic nervous system and clinical prognosis, because it can be non-invasively and easily measured, and the results are accurate and valuable. HRV is widely applied in cardiovascular disease fields. Exercise training is an important part of cardiac rehabilitation. Personalized sports rehabilitation therapy can effectively prevent the emergence of cardiovascular diseases, decrease the risk of recurrent cardiovascular events, and ameliorate dysfunction, as well as limitations in life, work, and social participation, caused by adverse cardiovascular events. However, sports rehabilitation can have drawbacks, in that improper training can cause injury, excessive fatigue, or even harmful cardiovascular events. To support future applications, this article reviews recent applications of HRV in sports rehabilitation for cardiovascular diseases.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0071

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Zhaoxin Zhu, Jianying Shen and Yan Zhang et al. Research Progress in Heart Rate Variability Applications in Exercise Rehabilitation for Cardiovascular Diseases. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0071

Post-Translational Modification of Drp1 is a Promising Target for Treating Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Mitochondria are essential for cell growth, fission, differentiation, and survival, particularly in undivided cells with high energy requirements, such as cardiomyocytes. The morphology and position of mitochondria change with the activity of mitochondrial fission proteins and mitochondrial fusion proteins. These regulatory mechanisms substantially affect cardiomyocyte energy supply and normal function. In mitochondrial fission, dynamin-related protein 1 (Drp1) is involved in the separation and degradation of damaged mitochondria, and accurately regulates mitochondrial renewal and number. Recent studies have revealed a variety of post-translational modification (PTMs) of Drp1, including phosphorylation, SUMOylation, acetylation, O-GlcNAcylation, and S-sulfhydration. These modifications ensure that Drp1 continues to function normally in various signaling pathways, by modulating its activity, stability, and subcellular localization.

This article provides an overview of the relationship between Drp1 PTMs and cardiovascular diseases such as heart failure, myocardial infarction, and myocardial ischemia-reperfusion, and describes how these modifications can be targeted and regulated, to help guide cardiovascular disease treatment.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0043

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Yingjie Ji, Han Zhou and Chen Yang et al. Post-Translational Modification of Drp1 is a Promising Target for Treating Cardiovascular Diseases. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0043