Category: News & Events

Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. The authors of this article aimed to identify promising AD biomarkers from high-throughput RNA expressing data.

In the GSE98770 dataset, differentially expressed mRNAs (DE-mRNAs) and microRNAs (DE-microRNAs) were identified through differentially expressed gene analysis and gene set enrichment analysis. The regulatory network between DE-mRNAs and DE-microRNAs was established, and hub genes were identified with Cytoscape.

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Whole-Exome Sequencing Identifies Three Novel TTN Variants in Chinese Families with Dilated Cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Dilated cardiomyopathy (DCM), a severe heart disease, is the leading cause of heart failure and sudden cardiac death worldwide. DCM is defined by a dilated and deficient systolic left ventricle (LV) and is a major risk factor for morbidity and mortality worldwide. DCM progression can be ascribed to genetic and non-genetic factors, including hypertension, infectious agents, toxins, and drugs.

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Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs.

To determine whether PECAM-1 and CVDs are causally associated, the authors of this article conducted a two-sample Mendelian randomization (TSMR) study.

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Graphical Abstracts Now Mandatory for All Original and Review Article Submissions

Effective 1 September 2024, all authors submitting original and review articles to Cardiovascular Innovations and Applications must include a Graphical Abstract that visually representsGraphical Abstracts the content of their paper. The Graphical Abstract should clearly introduce the research context, highlight the methodology, and present the primary outcomes.

A well-designed, visually engaging Graphical Abstract enhances an article’s impact by facilitating faster comprehension, encouraging interdisciplinary interest, and increasing visibility—especially on social media platforms. The Graphical Abstract should succinctly summarize the article in a visually engaging format, aimed at capturing the interest of a broad audience.

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Deciphering Cardiac Sarcomas: Etiology, Diagnosis, and Therapeutic Frontiers

Deciphering Cardiac SarcomasAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac sarcomas, characterized by their rarity and aggressive nature, pose substantial diagnosis and treatment challenges. This article emphasizes a multidisciplinary approach integrating clinical insights, advanced imaging techniques, histopathological analysis, and molecular diagnostics to achieve effective personalized patient management. It discusses the critical role of surgical resection in managing localized disease, complemented by adjuvant therapies such as chemotherapy and radiotherapy, to improve patient outcomes. Emerging treatments are highlighted including targeted therapies and immunotherapy and calls for sustained research efforts to better understand the molecular underpinnings of these tumors and develop more effective treatments. (more…)

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Diagnosing Immune Checkpoint Inhibitor-Induced Myocarditis: Insights, Challenges, and Uncertainties

Diagnosing Immune Checkpoint InhibitorAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Recent advancements in immunotherapy have substantially improved overall survival and quality of life among patients with cancer. Notably, immune checkpoint inhibitors (ICIs) have emerged as a revolutionary strategy, particularly in the management of advanced cancers.

However, the success of ICIs is accompanied by the challenge of immune-related adverse events. Although rare, cardiovascular adverse events associated with ICIs are associated with high fatality rates and rapid clinical progression, thereby necessitating timely intervention.

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Identification of a Novel DSP Variant in a Patient with Sudden Cardiac Death through Post-Mortem Genetic Investigation

Identification of a Novel DSP VariantAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Both DSP cardiomyopathy and plakophilin 2 are associated with arrhythmogenic right ventricular cardiomyopathies via a desmosomal mechanism. However, the diagnostic and risk stratification criteria for plakophilin 2-associated cardiomyopathy are less accurate for DSP cardiomyopathy.

In the era of genetic-based personalized medicine, gene-centric strategies are crucial for postmortem analysis and accurate risk assessment. Postmortem genetic testing is an efficient and rapid method to investigate potential disease-causing mechanisms.

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Cardiac Magnetic Resonance Visualization of the Myocardial Microstructure in Non-Ischemic Cardiomyopathies

Cardiac Magnetic Resonance Visualization of the Myocardial MicrostructureAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac magnetic resonance (CMR), a non-radiation based type of examination, can achieve the simultaneous comprehensive multi-parameter, multi-plane, and multi-sequence evaluation of the anatomical structure of the heart; and at the same time, determine systolic and diastolic function, and blood perfusion and tissue characteristics.

Traditional late gadolinium enhancement imaging based on CMR reflects focal replacement (more…)

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Adverse Outcomes in Non-ST-Elevation Acute Coronary Syndrome: A Cluster Analysis Study

Non-ST-Elevation Acute Coronary SyndromeAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) have diverse clinical trajectories and form a heterogeneous group. They exhibit differences in clinical and angiographic findings, laboratory parameters including platelet function, and the severity of concomitant pathology. These variations affect their clinical courses and prognosis. (more…)

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