Category: News & Events

Cardiac Rehabilitation in Patients with Advanced Heart Failure

Cardiac Rehabilitation in Patients with Advanced Heart FailureAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac rehabilitation (CR) remains an integral part of heart failure (HF) management, yet certain groups of patients with HF, particularly those with implantable devices, and those who are older and/or frail, are often precluded from CR. The authors of this article performed a narrative review discussing the benefits of CR in these groups of patients, highlighting evidence from the existing literature. Special considerations for this patient group are further discussed, including CR implementation for their long-term management. Hesitancy in referring vulnerable groups of patients with HF, specifically those with advanced HF, has led to poor outcomes in this patient cohort. However, the growing evidence supporting the use of CR is discussed, thus demonstrating the importance of HF (more…)

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Mechanical Thrombectomy System for the Treatment of Intermediate-Risk Acute Pulmonary Embolism: The CLEAR Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Mechanical thrombectomy is effective and safe for treating pulmonary embolism (PE). Although the Tendvia mechanical thrombectomy system has been validated in pigs, further evidence supporting its use in PE treatment is needed. This study was aimed at evaluating the safety and efficacy of the Tendvia system for intermediate-risk acute PE.

This prospective, single-arm, multicenter study included symptomatic patients with acute PE ≥18 years of age, with a right ventricular (RV)/left ventricular (LV) diameter ratio ≥0.9. The primary efficacy endpoint was the change in RV/LV diameter ratio from baseline to 48 hours postprocedure. The primary safety endpoint was the incidence of major adverse events (AEs), device-related death, 48-hour postprocedure major bleeding, pulmonary vascular injury, and cardiac injury.

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Comprehensive Bioinformatics Method to Explore Immune-Related Genes in the Pathogenesis of Myocardial Infarction

Announcing a new article publication for Cardiovascular Innovations and Applications journal.   This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as potential diagnostic and therapeutic targets.

Gene expression data were analyzed from three datasets: GSE29111 and GSE66360, which were combined as a training set, and GSE48060, which served as the validation set.

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Alternative RNA Splicing in Cardiac Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or the selection of alternative splice sites modify transcript isoforms, which can consequently affect RNA molecules, including mRNA and non-coding RNAs, in terms of their localization, regulation, and overall function.

In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long non-coding RNAs, can contribute to the development of cardiovascular diseases. In addition, multiple hereditary heart-related diseases are caused by mutations associated with AS.

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Enhancing the Diagnosis of Transient Ischemic Attacks Through Biomarker Innovation

Transient Ischemic Attacks DiagnosisAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. This study shows the potential of novel biomarkers in the diagnosis of TIA. Further research is warranted in testing more biomarkers including those omics markers for this purpose. Ultimately, to accurately identify TIAs from suspected cases will provide adequate and timely treatment and better patient care for those suffering with TIA.

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Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM) is a specific type of cardiomyopathy that is independent of hypertension and coronary artery disease, and is closely associated with the high incidence and mortality of heart failure in people with diabetes.

DCM causes microvascular disease, myocardial metabolic disorder, and myocardial fibrosis, thereby leading to left ventricular remodeling, diastolic and/or systolic dysfunction, and eventually progressing to congestive heart failure.

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A Panel of Blood Biomarkers for the Diagnosis of Transient Ischemic Attacks

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Accurate diagnosis of transient ischemic attacks (TIAs) is challenging. This study was aimed at analyzing blood biomarkers to distinguish TIAs from mimics.

The levels of eight candidate biomarkers were measured in 234 patients with suspected TIA, 103 of whom had TIA and 131 of whom had mimics. We compared the groups, examined the effects of the biomarkers via logistic regression, compared models with likelihood ratio tests, assessed predictive accuracy with receiver operating characteristic analysis, and optimized cutoff values with the PanelomiX algorithm.

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Intravenous Protamine Sulfate Shortens Compression Time After Coronary Angiography via Distal Transradial Access

Intravenous Protamine SulfateAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  With distal transradial access (dTRA), the postoperative compression time remains significantly longer than the recommended range via in practice. This study investigates whether intravenous protamine sulfate might shorten the postoperative compression time and increase safety after coronary angiography via dTRA.

In this retrospective study, patients who underwent coronary angiography were enrolled and divided into two groups. The study group received a slow intravenous injection of 15–20 mg protamine sulfate before sheath retraction. The primary endpoint was the puncture compression time after coronary angiography.

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Serum Extracellular Vesicle-derived microRNA Profiles in Patients with ST-segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

extracellular-vesicle-micrornas-ami-diagnostic-biomarkers.jpgAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.

Peripheral blood samples were collected from three patients with AMI and three healthy individuals, and serum EV total RNA was extracted. The miRNA differential expression profiles of serum EVs were obtained through next-generation sequencing combined with bioinformatics analysis.

In patients with AMI, compared with controls without AMI, 15 differentially expressed miRNAs (more…)

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Adipokines Pathogenesis in Heart Failure

Adipokines Pathogenesis in Heart FailureAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Many studies have reported that obesity causes heart failure (HF) pathogenesis. The elevated circulating levels of angiopoietin-like protein 2 (ANGPTL2) observed in patients with HF suggest potential links among elevated ANGPTL2 levels, metabolic disturbances, and inflammation. C1q/TNF-related protein 3 and C1q/TNF-related protein 9 are diminished in patients with HF with reduced ejection fraction, in proportion to disease severity, and are associated with elevated morbidity and mortality. (more…)

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