Category: News & Events

Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs.

To determine whether PECAM-1 and CVDs are causally associated, the authors of this article conducted a two-sample Mendelian randomization (TSMR) study.

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Graphical Abstracts Now Mandatory for All Original and Review Article Submissions

Effective 1 September 2024, all authors submitting original and review articles to Cardiovascular Innovations and Applications must include a Graphical Abstract that visually representsGraphical Abstracts the content of their paper. The Graphical Abstract should clearly introduce the research context, highlight the methodology, and present the primary outcomes.

A well-designed, visually engaging Graphical Abstract enhances an article’s impact by facilitating faster comprehension, encouraging interdisciplinary interest, and increasing visibility—especially on social media platforms. The Graphical Abstract should succinctly summarize the article in a visually engaging format, aimed at capturing the interest of a broad audience.

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Deciphering Cardiac Sarcomas: Etiology, Diagnosis, and Therapeutic Frontiers

Deciphering Cardiac SarcomasAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac sarcomas, characterized by their rarity and aggressive nature, pose substantial diagnosis and treatment challenges. This article emphasizes a multidisciplinary approach integrating clinical insights, advanced imaging techniques, histopathological analysis, and molecular diagnostics to achieve effective personalized patient management. It discusses the critical role of surgical resection in managing localized disease, complemented by adjuvant therapies such as chemotherapy and radiotherapy, to improve patient outcomes. Emerging treatments are highlighted including targeted therapies and immunotherapy and calls for sustained research efforts to better understand the molecular underpinnings of these tumors and develop more effective treatments. (more…)

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Diagnosing Immune Checkpoint Inhibitor-Induced Myocarditis: Insights, Challenges, and Uncertainties

Diagnosing Immune Checkpoint InhibitorAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Recent advancements in immunotherapy have substantially improved overall survival and quality of life among patients with cancer. Notably, immune checkpoint inhibitors (ICIs) have emerged as a revolutionary strategy, particularly in the management of advanced cancers.

However, the success of ICIs is accompanied by the challenge of immune-related adverse events. Although rare, cardiovascular adverse events associated with ICIs are associated with high fatality rates and rapid clinical progression, thereby necessitating timely intervention.

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Identification of a Novel DSP Variant in a Patient with Sudden Cardiac Death through Post-Mortem Genetic Investigation

Identification of a Novel DSP VariantAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Both DSP cardiomyopathy and plakophilin 2 are associated with arrhythmogenic right ventricular cardiomyopathies via a desmosomal mechanism. However, the diagnostic and risk stratification criteria for plakophilin 2-associated cardiomyopathy are less accurate for DSP cardiomyopathy.

In the era of genetic-based personalized medicine, gene-centric strategies are crucial for postmortem analysis and accurate risk assessment. Postmortem genetic testing is an efficient and rapid method to investigate potential disease-causing mechanisms.

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Cardiac Magnetic Resonance Visualization of the Myocardial Microstructure in Non-Ischemic Cardiomyopathies

Cardiac Magnetic Resonance Visualization of the Myocardial MicrostructureAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac magnetic resonance (CMR), a non-radiation based type of examination, can achieve the simultaneous comprehensive multi-parameter, multi-plane, and multi-sequence evaluation of the anatomical structure of the heart; and at the same time, determine systolic and diastolic function, and blood perfusion and tissue characteristics.

Traditional late gadolinium enhancement imaging based on CMR reflects focal replacement (more…)

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Adverse Outcomes in Non-ST-Elevation Acute Coronary Syndrome: A Cluster Analysis Study

Non-ST-Elevation Acute Coronary SyndromeAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) have diverse clinical trajectories and form a heterogeneous group. They exhibit differences in clinical and angiographic findings, laboratory parameters including platelet function, and the severity of concomitant pathology. These variations affect their clinical courses and prognosis. (more…)

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Prognostic Implications of Degenerative Mitral Regurgitation on Eligibility for TAVI

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Transcatheter aortic valve implantation (TAVI) has emerged as the primary treatment strategy for severe symptomatic aortic stenosis (AS) in the older population (>75 years of age) with high-risk surgical profiles.

The growing older population and the concomitant age-related high prevalence of degenerative AS, combined with evidence of the non-inferiority of the TAVI procedure over surgical aortic valve replacement in intermediate-risk patients, increase the potential number of TAVI candidates. Concerns regarding the higher costs of TAVI than surgical aortic valve replacement are balanced by its shorter length of hospitalization and lower acute complication costs.

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Cardiac Magnetic Resonance Imaging in Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Heart failure (HF) is a clinical syndrome with a wide variety of clinical presentations, pathophysiologies, and natural histories. HF is becoming more prevalent globally, thus increasing effects on healthcare systems. Cardiac magnetic resonance (CMR) imaging is a valuable tool for better understanding HF and its prognosis.

The commonly used reference standard of CMR cine imaging provides accurate assessment of chamber size and function. Phase contrast imaging can be used to assess the degree of valvular regurgitation and complex flow patterns. Stress perfusion imaging can detect subtle areas of ischemia and microvascular dysfunction.

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Clinical Implications and Procedural Complications in Patients with Patent Foramen Ovale Concomitant with Atrial Septal Aneurysm

Clinical Implications and Procedural Complications in PatientsAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Atrial septal aneurysm (ASA) is defined as excursion of the atrial septum exceeding 10 mm beyond the atrial septum into the right or left atrium, or a combined total excursion of 15 mm on the right and left sides during the cardiac cycle.

According to previous studies, 20–40% of patent foramen ovale (PFO) cases are accompanied by ASAs. ASA is associated with the presence of PFO, left atrial dysfunction, cryptogenic stroke, migraine, and arterial embolism, thus making closure of PFO in patients with concomitant ASA necessary but challenging. (more…)

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