News & Events Archives - CVIA Journal

Category: News & Events

Effects of Cardiac Abnormalities on the Brain, Revealed by Brain Magnetic Resonance Imaging and Genetics

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The heart is the central organ of the human circulatory system. Both congenital and acquired structural changes in the heart can lead to hemodynamic alterations affecting the function of various organs, including the brain. Recent advancements in magnetic resonance imaging (MRI) have provided further evidence of the heart’s influence on the brain.

Investigating this connection is crucial for understanding the pathological mechanisms through which cardiac abnormalities contribute to brain-related diseases, and providing additional support for the heart-brain axis theory.

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Association Between Malnutrition and Guideline-Directed Medical Therapy Utilization at Discharge in Hospitalized Patients with Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at identifying crucial gaps in guideline-directed medical therapy (GDMT) application among malnourished patients at Beijing Anzhen Hospital. Data from patients with heart failure (HF) admitted between January 1, 2018, and April 30, 2023, were analyzed. Malnutrition was assessed with Controlling Nutritional Status (CONUT) and Geriatric Nutritional Risk Index (GNRI) scores.

GDMT regimens were defined as follows. The triple-therapy regimen included β-blockers, renin-angiotensin system inhibitors (RASIs), and mineralocorticoid receptor antagonists (MRAs).

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Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection is a life-threatening condition with complex immunological underpinnings. This article explored the causal relationships among immune cells, inflammatory proteins, and aortic dissection, through Mendelian randomization analysis. A two-step Mendelian randomization approach was used to assess potential mediators, focusing on the roles of blood immune cells and inflammatory proteins.

GWAS data was analyzed for 731 immune cell traits, 91 inflammatory proteins, and aortic dissection. Single-nucleotide polymorphisms were used as instrumental variables, and analyses were conducted with inverse variance weighting and sensitivity tests to ensure robustness.

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Chronic Kidney Disease and Cognitive Dysfunction after Cardiac Surgery

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Patients with chronic kidney disease (CKD) often encounter cardiovascular complications, most commonly coronary heart disease. Although coronary artery bypass grafting is an effective treatment for this condition, many patients experience cognitive dysfunction after cardiac surgery.

The complex interactions among functional status, general anesthesia, cardiopulmonary bypass, and surgical trauma in patients with CKD elevate the risk of neurological issues and increase the mortality rates after surgery.

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Potential Therapeutic Targets of PANoptosis for Myocardial Infarction: A Summary-Data-Based Mendelian Randomization Study Integrating eQTL, mQTL, and Multi-GWAS Data

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Acute myocardial infarction (MI), a critical and dangerous manifestation of coronary heart disease resulting from arterial or bypass graft thrombosis, rapidly induces myocardial ischemia and hypoxia, and culminates in cardiac failure.

PANoptosis, an inflammasome-dependent, inflammatory form of programmed cell death, involves a complex molecular network in which pyroptosis, apoptosis, and necroptosis mediate apoptotic programs in an interconnected manner. However, the causal relationships and regulatory mechanisms linking MI and PANoptosis have not been clarified. In addition, DNA methylation regulates PANoptosis pathways, thereby mediating changes in cardiac diseases.

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MicroRNAs Have an Immunomodulatory Role in Diabetes Mellitus and Diabetic Cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Diabetic cardiomyopathy (DCM), an independent diabetes complication, is characterized by abnormalities in myocardial structure, function, and metabolism, including diminished myocardial contractility, myocardial hypertrophy, and fibrosis. Factors such as hyperglycemia, metabolic disorders, microangiopathy, inflammation, oxidative stress, and insulin resistance have been found to play important roles in DCM pathophysiology.

Recent research has shown that miRNAs are involved in processes such as myocardial cell proliferation, differentiation, and metastasis, and promote the progression of DCM. Despite these insights, the regulatory effects of miRNAs on immune function in DCM remain inadequately explored.

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Catheter Ablation as the First-Line Therapy for Atrial Fibrillation: Update on Evidence and Clinical Implications

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Therapy for atrial fibrillation has markedly evolved over the past two decades. Advancements in technology and growing therapeutic options have led to reexamination of the current evidence. New guidelines have also been updated and published across continents. This reappraisal of the contemporary data assesses the overall treatment strategies for patients with atrial fibrillation and examines how atrial fibrillation ablation ranks among the hierarchy of therapeutic modalities. The role of catheter ablation as a first-line therapy in selected patients with atrial fibrillation is emphasized, and a selective discussion of catheter ablation in patients with heart failure is included.

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Opioid-sparing Anesthesia Significantly Improves Early Postoperative Recovery after Cardiac Surgery: A Retrospective Cohort Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Mounting evidence indicates that opioid-sparing anesthesia (OSA) decreases opioid-related adverse events. This article examines whether OSA might improve initial recovery after cardiac surgery.

Data from patients who underwent elective heart surgery between July 2023 and July 2024 were analyzed. Eligible patients were divided into an OSA group or a control group. Patients in the OSA group received 0.5 to 1 μg·kg⁻¹ sufentanil and ultrasound-guided nerve block after anesthetic induction, whereas patients in the control group received traditional high-dose opioid management. Patients in both groups were managed with the same sedatives, muscle relaxants, and other drugs. The main outcome was the overall 15-item Quality of Recovery (QoR-15) survey score 24 hours after surgery. (more…)

Interventional Therapy in Pulmonary Embolism Treatment: Expanding Benefits and Advancing Safety

Acute pulmonary embolism (PE) remains a global health challenge with significant morbidity and mortality. High-risk PE, characterized by hemodynamic instability, and intermediate-risk PE, with evidence of right ventricular (RV) dysfunction, pose distinct therapeutic challenges. Traditionally, systemic thrombolysis and surgical embolectomy have been the primary therapeutic strategies. However, both approaches come with limitations, such as bleeding risks in thrombolysis and resource-intensive requirements in surgical embolectomy. In response, percutaneous catheter-directed therapies, including mechanical thrombectomy and catheter-directed thrombolysis (CDT), have emerged as promising alternatives.

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Comprehensive Strategies to Address Radiation-Induced Restrictive Cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Radiation-induced cardiomyopathy has become a significant clinical challenge with the increased use of thoracic radiation therapy. Recent technological advancements in radiation therapy, such as 3D conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), and proton therapy, have decreased cardiac exposure. Additional methods including multileaf collimation (MLC) cardiac shields, patient prone positioning, and the deep inspiration breath-hold (DIBH) technique further mitigate the effects of radiation on the heart. Post-therapy cardiac screening is crucial for timely intervention. Furthermore, the antioxidant properties of certain medications and herbal supplements may counteract radiation-induced oxidative stress. Notably, statins, angiotensin converting enzyme inhibitors, and natural products have demonstrated protective effects against radiation-induced cellular damage. (more…)

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