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Serum Extracellular Vesicle-derived microRNA Profiles in Patients with ST-segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.

Peripheral blood samples were collected from three patients with AMI and three healthy individuals, and serum EV total RNA was extracted. The miRNA differential expression profiles of serum EVs were obtained through next-generation sequencing combined with bioinformatics analysis.

In patients with AMI, compared with controls without AMI, 15 differentially expressed miRNAs (more…)

Adipokines Pathogenesis in Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Many studies have reported that obesity causes heart failure (HF) pathogenesis. The elevated circulating levels of angiopoietin-like protein 2 (ANGPTL2) observed in patients with HF suggest potential links among elevated ANGPTL2 levels, metabolic disturbances, and inflammation. C1q/TNF-related protein 3 and C1q/TNF-related protein 9 are diminished in patients with HF with reduced ejection fraction, in proportion to disease severity, and are associated with elevated morbidity and mortality. (more…)

Percutaneous Mitral Valve Repair with the PASCAL Ace System in an Older Patient with a Dislocated Annuloplasty Ring: The First Case Report in Italy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The Edwards PASCAL Transcatheter Mitral Valve Repair System Study (CLASP) and CLASP IID trials assessed the PASCAL system from Edwards Lifesciences for mitral valve repair. CLASP I demonstrated the system’s safety and effectiveness in decreasing mitral regurgitation and ameliorating patient symptoms. CLASP IID further validated the system’s benefits in patients with complex mitral regurgitation who were not ideal candidates for conventional surgery. Together, these trials have provided strong evidence that the PASCAL system is a promising and safe solution for mitral valve repair, particularly for patients at high risk of requiring invasive (more…)

Inflammation in Heart Failure: Mechanisms and Therapeutic Strategies

Announcing a new article publication for journal. Cardiovascular disease remains a leading cause of death and disability worldwide. Heart failure (HF) is the end stage of various cardiovascular diseases. Despite recent advancements in understanding of HF pathogenesis and treatment, the prognosis of patients with HF remains poor. Inflammation is a key player in the development of HF, and its role in the pathogenesis of HF has been extensively studied. Inflammation is associated with elevated HF risk and adverse prognosis. Targeting cardiac inflammation has been suggested as a promising treatment strategy for HF. However, almost all clinical trials on the anti-inflammatory treatment of HF have not indicated improved clinical outcomes, and some have reported deterioration of the condition, possibly because of limited understanding (more…)

A Large-Diameter Thrombus Retrieving Device for Intermediate-Risk Acute Pulmonary Embolism Treatment: A Single-Arm Prospective Clinical Trial

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Globally, acute pulmonary embolism (PE) is the third leading cause of cardiovascular-related deaths after myocardial infarction and stroke. Several studies have reported increased annual incidence of PE and consequently social medical burden. Determining how to treat acute PE more safely and effectively, while decreasing long-term complications, remains an important issue in medicine.

The aim of this study was to report the results of a single-arm clinical trial in (more…)

Quadricuspid Aortic Valve: A Rare Congenital Anomaly Presenting in Adulthood with Severe Aortic Regurgitation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This article discusses the diagnosis of quadricuspid aortic valve (QAV), highlighting a common presentation – detection in midlife following symptoms of severe regurgitation confirmed by transthoracic echocardiography (TTE). The delayed diagnosis underscores how valve dysfunction often emerges later in life.

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Supraventricular Tachycardias in Patients with Congenitally Corrected Transposition of the Great Arteries

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Reentrant supraventricular tachycardias (SVTs) in cc-TGA patients often involve complex reentrant circuits, including twin AV nodes and multiple accessory pathways, frequently associated with Ebstein’s anomaly of the tricuspid valve. Successful management requires a thorough understanding of the unique anatomy and physiology of the conduction system in cc-TGA. Curative interventions like ablation require clear understanding of the anatomical challenges that present in these patients and the potential for multiple and complex reentrant circuits.

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Surgical Treatment of Aortic Annulus Damaged by Infective Endocarditis: A Single-Center Experience

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Infective endocarditis (IE) is a serious infection caused by pathogenic bacteria that travel through the bloodstream and colonize the endocardium, thus resulting in rapid progression, numerous complications, and high mortality. Despite the emergence of new diagnostic and therapeutic strategies, the 1-year mortality rate has not improved and remains at 30%.

Surgical management of IE involving the aortic annulus is critical, because pharmacologic therapy alone is usually insufficient to address the structural damage and hemodynamic instability caused by this severe infection.

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Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface. Atrial fibrillation (AF) is the most prevalent clinically relevant cardiac rhythm condition.Patients with persistent AF have higher levels of C-X-C motif chemokine ligand 8 (CXCL8) than those with paroxysmal AF, thus suggesting a link between long-lasting AF and a low-grade inflammatory response. A newly identified function of C-X-C motif chemokine receptor 2 (CXCR2) is promoting monocyte infiltration of the atria, thus accelerating atrial remodeling and AF after hypertension.

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Cardiac Rehabilitation Knowledge, Attitudes, and Practice among Patients with Heart Failure and Cardiology Healthcare Providers

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac rehabilitation (CR) typically consists of physical activity supplemented with lifestyle modifications, including smoking cessation, adherence to a healthy diet, stress management, medication adherence management, risk factor reduction, psychosocial support, and education. Because CR involves important changes in lifestyle and physical activity, self-management is central to successful CR. Proper knowledge regarding, and attitudes toward, CR are key to effective self-management. Consequently, identifying knowledge gaps, misconceptions, and misunderstandings regarding CR could improve attitudes and practice. (more…)

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