News & Events Archives - CVIA Journal

Category: News & Events

Supraventricular Tachycardias in Patients with Congenitally Corrected Transposition of the Great Arteries

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Reentrant supraventricular tachycardias (SVTs) in cc-TGA patients often involve complex reentrant circuits, including twin AV nodes and multiple accessory pathways, frequently associated with Ebstein’s anomaly of the tricuspid valve. Successful management requires a thorough understanding of the unique anatomy and physiology of the conduction system in cc-TGA. Curative interventions like ablation require clear understanding of the anatomical challenges that present in these patients and the potential for multiple and complex reentrant circuits.

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Surgical Treatment of Aortic Annulus Damaged by Infective Endocarditis: A Single-Center Experience

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Infective endocarditis (IE) is a serious infection caused by pathogenic bacteria that travel through the bloodstream and colonize the endocardium, thus resulting in rapid progression, numerous complications, and high mortality. Despite the emergence of new diagnostic and therapeutic strategies, the 1-year mortality rate has not improved and remains at 30%.

Surgical management of IE involving the aortic annulus is critical, because pharmacologic therapy alone is usually insufficient to address the structural damage and hemodynamic instability caused by this severe infection.

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Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface. Atrial fibrillation (AF) is the most prevalent clinically relevant cardiac rhythm condition.Patients with persistent AF have higher levels of C-X-C motif chemokine ligand 8 (CXCL8) than those with paroxysmal AF, thus suggesting a link between long-lasting AF and a low-grade inflammatory response. A newly identified function of C-X-C motif chemokine receptor 2 (CXCR2) is promoting monocyte infiltration of the atria, thus accelerating atrial remodeling and AF after hypertension.

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Cardiac Rehabilitation Knowledge, Attitudes, and Practice among Patients with Heart Failure and Cardiology Healthcare Providers

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac rehabilitation (CR) typically consists of physical activity supplemented with lifestyle modifications, including smoking cessation, adherence to a healthy diet, stress management, medication adherence management, risk factor reduction, psychosocial support, and education. Because CR involves important changes in lifestyle and physical activity, self-management is central to successful CR. Proper knowledge regarding, and attitudes toward, CR are key to effective self-management. Consequently, identifying knowledge gaps, misconceptions, and misunderstandings regarding CR could improve attitudes and practice. (more…)

The Expanding Role of Drug-Coated Balloons and Endothelial Dynamic Strain Assessment in the Treatment of De Novo Atherosclerotic Coronary Artery Disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The potential for drug-coated balloons (DCB) as a primary treatment for de novo atherosclerotic coronary artery disease in larger vessels requires more research. This study highlights the potential for DCB in various sized vessels. The thorough assessment of the target coronary vasculature through computer programs helps to compare coronary arteries and their lesions with the aim of assessing the impact of intervention.

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Role of the E3 Ubiquitin Ligase CBL Family in Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The ubiquitin-proteasome system is a fundamental cellular process increasingly considered for diagnostic and therapeutic strategies. Current research on Casitas B-lineage lymphoma (CBL) proteins primarily focuses on understanding its precise roles in the development of different diseases and exploring the feasibility of targeting CBL as a potential therapeutic target by inhibiting or enhancing its function.

On the one hand, blocking the interaction between Casitas B-lineage lymphoma and E2 by small molecules targeting the RING domain of CBL may enhance the activity of CBL-b and c-Cbl, potentially offering therapeutic value in cancer treatment. On the other hand, targeted deletion of the Casitas B-lineage lymphoma gene in specific cells can suppress CBL protein expression levels.

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Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. The authors of this article aimed to identify promising AD biomarkers from high-throughput RNA expressing data.

In the GSE98770 dataset, differentially expressed mRNAs (DE-mRNAs) and microRNAs (DE-microRNAs) were identified through differentially expressed gene analysis and gene set enrichment analysis. The regulatory network between DE-mRNAs and DE-microRNAs was established, and hub genes were identified with Cytoscape.

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Whole-Exome Sequencing Identifies Three Novel TTN Variants in Chinese Families with Dilated Cardiomyopathy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Dilated cardiomyopathy (DCM), a severe heart disease, is the leading cause of heart failure and sudden cardiac death worldwide. DCM is defined by a dilated and deficient systolic left ventricle (LV) and is a major risk factor for morbidity and mortality worldwide. DCM progression can be ascribed to genetic and non-genetic factors, including hypertension, infectious agents, toxins, and drugs.

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The Plausible Role of Vascular Adhesion Molecules in Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Vascular Adhesion Molecules (VAMs) appear to play important roles in the development of Cardiovascular Diseases (CVD). The roles of these molecules in mediating inflammation, endothelial dysfunction, and plaque formation suggest that they may be important as both biomarkers and therapeutic targets.

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Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs.

To determine whether PECAM-1 and CVDs are causally associated, the authors of this article conducted a two-sample Mendelian randomization (TSMR) study.

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