Category: News & Events

Immediate Effects of Calf Muscle Release via Foam Rolling and Active Stretching on Blood Pressure, Heart Rate and the Rate Pressure Product in People with High-Normal Blood Pressure – A Comparative Study

High normal blood pressure

High normal blood pressure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. High-normal blood pressure (i.e., 130–139/85–89 mmHg) has hazardous ratio for both coronary heart disease and stroke, because of day to day variations in blood pressure; consequently, prevention through lifestyle modification is essential.Although numerous studies have examined stretching and myofascial release to lower blood pressure, (more…)

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Identification of Arrhythmia-Associated Gene Mutations in Chinese Patients with Primary Electrical Disorders or Sudden Cardiac Death

Identification-of-Arrhythmia-Associated-Gene-MutationAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Sudden cardiac death (SCD), unexpected death based on sudden cardiac ejection cessation, accounts for 15–20% of unnatural deaths in developed countries. Primary electrical disorders (PEDs), a group of cardiac rhythm abnormalities without detectable structural heart disease, are a major cause of SCD in people younger than 35 years of age. (more…)

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Reproducibility of a New Method to Assess Endothelial Function According to Peripheral Arterial Volume

Endothelial FunctionAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. The assessment of endothelial function is crucial for understanding cardiovascular disease progression. Reliable, convenient non-invasive methods are necessary for evaluating endothelial function. Peripheral arterial volume (PAV), measured at the fingertip, is a novel approach for which limited reproducibility data are available. (more…)

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Four-Dimensional XStrain Echocardiographic Assessment of Left Ventricular Strain and Rotational Mechanics

4D XStrain Speckle Tracking EchocardiographyAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Because of its excellent ability to non-invasively assess left ventricular (LV) systolic function, two-dimensional speckle tracking echocardiography (STE) is increasingly being used in echocardiographic laboratories worldwide. Two-dimensional STE is the most sought-after method to evaluate LV strain, rotation, twist and torsion. (more…)

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Transcatheter Aortic Valve Replacement in Patients ≥80 and <80 Years of Age with Aortic Valve Stenosis at Moderate Surgical Risk: Findings from an Observational Study in the Vietnamese Population

Transcatheter Aortic Valve ReplacementAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. The increasing number of elderly patients with severe aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) has prompted concerns regarding their clinical outcomes compared with the younger population. This study evaluated the outcomes of TAVR on the basis (more…)

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Pregnancy History is Critical in Our Female Patients

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Cardiovascular disease remains the leading cause of death amongst women. Pregnancy reflects a time of significant cardiovascular stress during a woman’s life, with associated significant hemodynamic changes that can exacerbate underlying cardiovascular disease (CVD) or un-mask previously unknown CVD conditions. Women are now advancing in age prior to conception and entering childbearing years with a higher incidence of CVD conditions and risk factors. In turn, pregnancy complications and other reproductive conditions can pre-dispose to future cardiovascular risk. Thus, it is important to recognize pregnancy and reproductive history, as this can also serve as an important window into future cardiovascular disease risk.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0014

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Ki Park. Pregnancy History is Critical in Our Female Patients. CVIA. 2024. Vol. 9(1). DOI: 10.15212/CVIA.2024.0014

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A 24-Week, Multi-Center, Randomized, Open-Label Clinical Trial Comparing the Effects of Xuezhikang and Atorvastatin on Glucose Metabolism in Patients with Dyslipidemia and Prediabetes (XTREME Study): Design of the Study Protocol

Announcing a new article publication for Cardiovascular Innovations and Applications journal.   Statins, a first-line therapeutic option for atherosclerotic cardiovascular disease (ASCVD), have prompted concerns regarding dysglycemia and diabetes, thus posing a dilemma in treating patients with prediabetes. Xuezhikang (XZK) decreases blood cholesterol levels without affecting glucose metabolism, and may serve as a potential substitute.

The XTREME study is a prospective, randomized, open-label, multi-center trial evaluating whether XZK 1200 mg/d, compared with atorvastatin 20 mg/d, has favorable effects on HbA1c levels after 24 weeks of treatment in patients with dyslipidemia and prediabetes. After a 1-week run-in period for adherence assessment, the study will randomly assign (1:1) 392 patients meeting the protocol inclusion criteria to one of two treatment groups: an experimental group (XZK 1200 mg/day) or a control group (atorvastatin 20 mg/day). All participants will be recruited from approximately 20 Chinese medical centers. The primary endpoint will be change in HbA1c level from baseline to 24 weeks, or before anti-diabetic therapy initiation within 24 weeks. The key secondary outcomes will include other biomarkers reflecting blood glucose or lipid metabolism.

Delaying diabetes is desirable for individuals with prediabetes. The XTREME trial presents a unique opportunity to demonstrate whether XZK might provide an alternative to statins for patients with dyslipidemia and prediabetes.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0010

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Lan Fu, Yiqun Zhang and Xin Du et al. A 24-Week, Multi-Center, Randomized, Open-Label Clinical Trial Comparing the Effects of Xuezhikang and Atorvastatin on Glucose Metabolism in Patients with Dyslipidemia and Prediabetes (XTREME Study): Design of the Study Protocol. CVIA. 2024. Vol. 9(1). DOI: 10.15212/CVIA.2024.0010

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Identification of Potential Targets of Stress Cardiomyopathy by a Machine Learning Algorithm

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Stress cardiomyopathy (SCM) is a reversible, self-limiting condition that manifests as left ventricular insufficiency. The incidence of stress cardiomyopathy has increased because of increasing mental and social stress, but the exact pathophysiological mechanisms remain unclear.

To elucidate the critical molecules in the pathogenesis of SCM and the functional changes that they mediate, data for a healthy control group and stress cardiomyopathy (SCM) group was downloaded from the Gene Expression Omnibus database, differential analysis was performed, and the results of GO and KEGG enrichment analysis was analysed to describe SCM-associated genes and functions. Lasso, random forest, SVM-RFM, and Friends analysis were used to screen hub genes; CIBERSORT and MCPcounter were used to explore the relationship between SCM and immunity; and an animal model of SCM was constructed to conduct bidirectional verification of the obtained results.

In total, 21 samples (6 healthy, 15 SCM) were used in this study. Overall, 39 DEGs (absolute fold change ≥ 1; P < 0.05), including 23 upregulated and 16 downregulated genes in SCM, were extracted. Three common hub genes (PLAT, SEMA6B, and CRP) were finally screened. It was further confirmed that functional changes in SCM were concentrated in immunity and coagulation functions.

Three key genes (PLAT, SEMA6B, and CRP) in SCM were identified by machine learning, and the major functional changes leading to SCM, and relationships of SCM with immunity, were identified.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0011

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Xuexin Jin, Xuanrui Ji and Hongpeng Yin et al. Identification of Potential Targets of Stress Cardiomyopathy by a Machine Learning Algorithm. CVIA. 2024. Vol. 9(1). DOI: 10.15212/CVIA.2024.0011

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