Tag: Therapeutic targets

Drug Development and Promising Therapeutic Targets for Coronary Artery Disease: Current Landscape and Future Prospects: CVIA State-of-the-Art Review

Announcing a new article publication for Cardiovascular Innovations and Applications. Coronary artery disease (CAD) remains the leading cause of death globally, despite the limited efficacy of current pharmacological therapies. The need for safer and more effective treatment strategies has never been more urgent. This review provides a contemporary overview of advances in CAD drug development. Novel lipid-lowering agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and angiopoietin-like protein 3 (ANGPTL3) inhibitors, anti-inflammatory therapies targeting interleukin pathways, and metabolic modulators have expanded the therapeutic landscape. Concurrently, precision medicine and drug repurposing approaches, informed by genomic profiling and biomarker-based stratification, are transforming the framework of CAD therapy. The integration of artificial intelligence into drug discovery further accelerates innovation.

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Roles of Mitochondrial Quality Control in the Pathogenesis of Atherosclerosis

Mitochondrial Quality Control (MQC)Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Mitochondrial quality control (MQC) mechanisms – including biogenesis, dynamics, mitophagy, proteostasis, the unfolded protein response, and mitochondrial-derived vesicles – play critical roles in the development of atherosclerosis. Dysregulation of these processes can lead to mitochondrial dysfunction, and subsequently the initiation of a pathological cascade characterized by oxidative stress, chronic inflammation, and the accumulation of lipids within arterial walls. Specifically, ROS overproduction and redox state imbalance are key molecular aspects that exacerbate mitochondrial damage, and create a self-perpetuating cycle of cellular injury and disease progression.

Emerging therapeutic strategies targeting the modulation of MQC have promise in attenuating atherosclerotic progression by restoring mitochondrial biogenesis, restoring the balance of fusion and fission dynamics, enhancing the clearance of damaged mitochondria, and improving protein homeostasis. (more…)

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