Left Atrial Appendage Occlusion Archives

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The number of structural heart disease interventions has greatly increased in the past decade. Moreover, interest in the sex-specific outcomes of various cardiovascular conditions and procedures has increased. The authors of this article discuss the sex differences in the clinical profiles and outcomes of patients undergoing the most commonly performed structural procedures: transcatheter aortic valve replacement, transcatheter edge to edge repair of the mitral and tricuspid valve, transcatheter pulmonary valve replacement, patent foramen ovale closure and left atrial appendage occlusion. The potential reasons for these differences are reviewed and the authors emphasize the importance of increasing the representation of women in randomized clinical trials, to understand these differences and support the application of these cutting-edge technologies.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0049

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Lina Ya’Qoub, Jelena Arnautovic and Nadeen N. Faza et al. Sex Differences in Transcatheter Structural Heart Disease Interventions: How Much Do We Know? CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0049

Announcing a new article publication for Cardiovascular Innovations and Applications journal.

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is increasing in incidence and prevalence worldwide. AF significantly increases the risk of intracardiac thrombus formation and, if left untreated, ischemic stroke. In patients with nonvalvular AF (NVAF), the left atrial appendage (LAA) has been determined to be the source of thrombus development in 91% to 99% of cases. In this regard, oral anticoagulants (OACs) have become the standard treatment for stroke prevention in most patients with AF; however, OACs are associated with a risk of bleeding complications, and their efficacy depends on optimal patient compliance. Among alternative approaches to embolic stroke prevention, surgical LAA excision for stroke prevention for valvular AF was attempted as early as the late 1940s. LAA excision remains recommended in surgical guidelines for patients with NVAF requiring open-heart coronary bypass or valvular replacement/repair surgeries. However, owing to the traumatic/invasive nature and suboptimal outcomes of conventional surgical LAA intervention, clinical application of this approach is limited in current cardiology practice. Percutaneous LAA occlusion (LAAO) is increasingly being performed as an alternative to OAC for stroke prevention, particularly in patients with elevated bleeding risk.

Substantial progress has been made in percutaneous LAAO therapy since its inception approximately 20 years ago. This article systematically reviews the literature leading to the development of LAAO and the evidence-based clinical experience supporting the application of this treatment strategy for NVAF, with a focus on recently published critical evaluations of US FDA and CE mark approved LAAO devices. Future perspectives regarding knowledge and technology gaps are also discussed, recognizing the many ongoing clinical trials that are likely to be transformative and the critical unanswered questions regarding LAAO therapy.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0026

Xinqiang Han, Jianzeng Dong and David G. Benditt. Percutaneous Left Atrial Appendage Occlusion Therapy: Past, Present, and Future. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0026

CVIA Journal

Tag: Left Atrial Appendage Occlusion

Sex Differences in Transcatheter Structural Heart Disease Interventions: How Much Do We Know?

Percutaneous Left Atrial Appendage Occlusion Therapy: Past, Present, and Future