Tag: Heart Failure Therapy

Nomogram-Based Prediction of Mortality after Cardiac Resynchronization Therapy in Patients with Heart Failure

Nomogram-Based Prediction of Mortality after Cardiac Resynchronization Therapy in Patients with Heart FailureAnnouncing a new article publication for Cardiovascular Innovations and Applications journal.  Heart failure (HF) with reduced ejection fraction (HFrEF; LVEF ≤ 35%) affects more than 64 million people globally. The 5-year all-cause mortality exceeds 40% among this population. CRT is a cornerstone treatment for patients with HFrEF with left bundle branch block, prolonged QRS complex duration (ventricular depolarization interval ≥ 150 ms on an electrocardiogram), and New York Heart Association (NYHA) class II–IV symptoms despite optimal medical therapy. However, many patients remain at high risk of mortality post-CRT, particularly those who develop new-onset atrial fibrillation (NOAF), which can disrupt resynchronization and worsen prognosis. Existing prognostic models often do not include NOAF and may lack precision.

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Current Understanding and Evidence Regarding Qiliqiangxin (QLQX) in Heart Failure Treatment: From Basic to Clinical Research

Illustration of Qiliqiangxin (QLQX) mechanisms and clinical effects in heart failure treatment, from basic research to clinical application.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Qiliqiangxin (QLQX), a traditional Chinese medicine (TCM) formulation, has shown therapeutic potential in heart failure (HF) through its multifaceted mechanisms. This review article synthesizes preclinical and clinical evidence, highlighting the ability of QLQX to modulate cardiac remodeling, inflammation, fibrosis, and neurohormonal activation. Preclinical studies have revealed that the bioactive components of QLQX target peroxisome proliferator-activated receptor γ, mitochondrial metabolism, and calcium transport. Clinically, QLQX capsule decreases N-terminal pro B-type natriuretic peptide levels and improves functional outcomes in chronic HF. (more…)

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