Tag: coronary heart disease

Model for Patients with Multivessel Coronary Artery Lesions in the Highlands Region (Qinghai Province, Northwest China)

Announcing a new article publication for Cardiovascular Innovations and Applications journal.

The severity and prognosis of coronary artery disease are closely associated with treatment strategy choice. To achieve timely, accurate, early selection of a suitable treatment plan and assess patients’ prognosis, the authors of this article developed an effective predictive model for early identification of high-risk patients according to lesion severity.

Among the 510 patients with chest pain admitted to the Qinghai Red Cross Hospital between August 2018 and October 2019, 386 had coronary artery disease detected by coronary angiography. A total of 24 demographic characteristics and serum markers were analyzed in study participants. Least absolute shrinkage and selection operator regression was used to select variables, and multivariate logistic regression was used to build predictive models by using nominal plots. The discriminatory power of the models was evaluated with the area under the receiver operating characteristic curve (AUC). Predictive models were calibrated with calibration plots and the Hosmer–Lemeshow test. Their clinical validity was evaluated via decision curve analysis.

Data were randomly divided (7:3) into training (358 cases) and test (152 cases) sets. The predictive model included sex, age, smoking status, heart rate, systolic blood pressure, diastolic blood pressure, albumin, urea nitrogen, creatinine, uric acid, total cholesterol, and high-density lipoprotein cholesterol as predictors. The AUCs for the training and test sets were 0.793 and 0.732, respectively. The predictive model showed a good fit, and decision curve analysis indicated the clinical validity of the predictive model.

An effective risk predictive model was developed with good clinical value for predicting multivessel disease. Smoking cessation, lowering creatinine, and increasing HDL cholesterol concentrations might decrease the risk of developing multivessel disease, thereby avoiding severe disease.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0084

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Jun Li, Haixia Qin and Jiuping Zhao et al. Model for Patients with Multivessel Coronary Artery Lesions in the Highlands Region (Qinghai Province, Northwest China). CVIA. 2024. Vol. 9(1). DOI: 10.15212/CVIA.2023.0084

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Long-term Effects of Nicorandil Combined with Dihydropyridine Calcium Channel Blockers on Cardiovascular Outcomes in Patients with Coronary Heart Disease: A Real-world Observational Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at investigating whether the addition of nicorandil to a dihydropyridine calcium channel blocker (DHP-CCB) regimen might decrease the occurrence of major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD).

A multicenter, retrospective, real-world study was conducted. Between August 2002 and March 2020, 7413 eligible patients with CHD were divided into DHP-CCB plus nicorandil combination (n = 1843) and DHP-CCB (n = 5570) treatment groups. The primary outcome was MACE, defined as a composite of myocardial infarction, stroke, and all-cause mortality. Propensity score matching was used to adjust for confounding factors.

After propensity score matching, combination therapy, compared with DHP-CCBs alone, was associated with a lower risk of MACE (HR: 0.80, 95% CI: 0.67–0.97). The combination group also had a lower risk of stroke (HR: 0.55, 95% CI: 0.44–0.69), but not myocardial infarction (HR: 1.21, 95% CI: 0.91–1.61) or all-cause mortality (HR: 1.24, 95% CI: 0.63–2.44). Subgroup analysis revealed more prominent benefits of the combined treatment on MACE in patients with than without diabetes.

The combination of nicorandil and DHP-CCBs may be more beneficial than DHP-CCBs alone in decreasing long-term risks of MACE and stroke in patients with CHD.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0072

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Jia Cheng, Zixuan Zhang and Hongyang Shu et al. Long-term Effects of Nicorandil Combined with Dihydropyridine Calcium Channel Blockers on Cardiovascular Outcomes in Patients with Coronary Heart Disease: A Real-world Observational Study. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0072

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Robotic Percutaneous Coronary Intervention in Coronary Heart Disease: Applications and Recent Advances

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Traditional percutaneous coronary intervention (T-PCI) has long been an effective method for treating coronary heart disease (CHD), but the radiation hazards and orthopedic injuries among T-PCI operators are concerning. These problems have been mitigated with the emergence of robotic percutaneous coronary intervention (R-PCI), which is expected to increase intervention accuracy and safety. In this review, the current status of PCI development is summarized, including robot systems, and PCI application and evaluation. T-PCI and R-PCI are compared to identify the benefits for patients and physicians. In addition, a new R-PCI system is described, R-PCI WSER-CD01, which incorporates multi-instrument collaborative delivery and provides full-process assistance in minimally invasive vascular intervention. This system introduces three key innovations that address safety concerns, and improve the accuracy, wire compatibility, and remote operation capabilities of existing of vascular intervention robot systems. Finally, prospects for the development of R-PCI are discussed. As an emerging technology, R-PCI aligns well with the trends of precision medicine and telemedicine, and therefore warrants continued innovation.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0062

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Yan-Jun Song, Zechen Liu and Weihua Song et al. Robotic Percutaneous Coronary Intervention in Coronary Heart Disease: Applications and Recent Advances. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0062

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Changes in Autonomic Nervous System Function in Patients greater than 60 Years of Age with Coronary Heart Disease, and Normotension or Hypertension: An Observational Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  The aim of this observational study was to perform in-depth analysis of autonomic nervous system function in patients older than 60 years of age with coronary artery disease, and normotension or hypertension.

A total of 104 patients older than 60 years with coronary heart disease (CHD) were divided into a normotension group and hypertension (HT) group, and 24-hour Holter monitoring was performed to assess autonomic function.

Among the 104 patients with CHD analyzed, 52 had normotension, and 52 had hypertension. The 24-hour Holter results based on time-domain methods indicated that the values of the time-domain parameters of heart rate variability were significantly lower in the CHD+HT group than the CHD group. Furthermore, during both the daytime and nighttime, the time-domain parameters were significantly lower in the CHD+HT group than the CHD group. No difference was observed in autonomic function during the daytime and nighttime in each group. Values of frequency-domain parameters of heart rate variability were also significantly lower in the CHD+HT group than the CHD group. More patients in the CHD+HT group than the CHD group received percutaneous coronary intervention (57.69% vs. 50% χ2=0.619, P=0.55). In 12 months of follow-up, we found no significant differences in rehospitalization for unstable angina and target lesion revascularization between patients with CHD with normotension versus hypertension.

The heart autonomic nervous system dysfunction in patients older than 60 years with CHD with hypertension was more severe than that in patients with CHD with normotension, and therefore, should receive greater clinical attention.

https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2023.0038

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Facebook.

Jing-Xiu Li, Jing Wang and Bei-Bei Ding et al. Changes in Autonomic Nervous System Function in Patients >60 Years of Age with Coronary Heart Disease, and Normotension or Hypertension: An Observational Study. CVIA. 2023. Vol. 8(1). DOI: 10.15212/CVIA.2023.0038

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