Tag: Cardiac Arrest

Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest

Cyclic GMP-AMP synthaseAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available. Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a potential contributor to cardiac dysfunction. This study was aimed at investigating the role of cGAS in post-CA cardiac dysfunction.

In vivo, in rats with ventricular fibrillation (VF)-induced CA, a selective cGAS inhibitor (RU.521) was used to specifically inhibit cGAS activity, thereby blocking its downstream signaling pathway. In vitro, hypoxia and reoxygenation (H/R) were used to stimulate H9C2 cardiomyocytes, and a specific siRNA targeting cGAS was applied to knock down cGAS expression. (more…)

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Identification of Arrhythmia-Associated Gene Mutations in Chinese Patients with Primary Electrical Disorders or Sudden Cardiac Death

Identification-of-Arrhythmia-Associated-Gene-MutationAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. Sudden cardiac death (SCD), unexpected death based on sudden cardiac ejection cessation, accounts for 15–20% of unnatural deaths in developed countries. Primary electrical disorders (PEDs), a group of cardiac rhythm abnormalities without detectable structural heart disease, are a major cause of SCD in people younger than 35 years of age. (more…)

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