Tag: aortic dissection

Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection is a life-threatening condition with complex immunological underpinnings. This article explored the causal relationships among immune cells, inflammatory proteins, and aortic dissection, through Mendelian randomization analysis. A two-step Mendelian randomization approach was used to assess potential mediators, focusing on the roles of blood immune cells and inflammatory proteins.

GWAS data was analyzed for 731 immune cell traits, 91 inflammatory proteins, and aortic dissection. Single-nucleotide polymorphisms were used as instrumental variables, and analyses were conducted with inverse variance weighting and sensitivity tests to ensure robustness.

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Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321

Announcing a new article publication for Cardiovascular Innovations and Applications journal.  Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. The authors of this article aimed to identify promising AD biomarkers from high-throughput RNA expressing data.

In the GSE98770 dataset, differentially expressed mRNAs (DE-mRNAs) and microRNAs (DE-microRNAs) were identified through differentially expressed gene analysis and gene set enrichment analysis. The regulatory network between DE-mRNAs and DE-microRNAs was established, and hub genes were identified with Cytoscape.

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