Tag: abdominal aortic aneurysm

Multi-Omics Exploration of Risk Factors and Pathways Linking Respiratory Conditions and Abdominal Aortic Aneurysm

Multi-Omics Exploration of Risk Factors and Pathways Linking Respiratory Conditions and Abdominal Aortic AneurysmAnnouncing a new article publication for Cardiovascular Innovations and Applications journal. This editorial highlights a landmark study that applies an integrative multi-omics framework to uncover a causal connection between chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). Through the combined use of bidirectional Mendelian randomization (MR), tissue-specific expression quantitative trait loci (eQTL) analysis, single-cell RNA sequencing (scRNA-seq), and phenome-wide association studies (PheWAS), the study provides robust genetic and molecular evidence linking the two diseases.

A key discovery is the identification of 48 genes associated with both conditions, including KIF3A, a gene found to inhibit disease activity in both COPD and AAA. The integration of scRNA-seq data allowed localization of relevant genes—such as PLTP, RIF1, and IFI27L2—to immune and stromal cells, providing insights into tissue-specific mechanisms of pathogenesis.

Read more: https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2025.0019

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