Current Understanding and Evidence Regarding Qiliqiangxin (QLQX) in Heart Failure Treatment: From Basic to Clinical Research

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Illustration of Qiliqiangxin (QLQX) mechanisms and clinical effects in heart failure treatment, from basic research to clinical application.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Qiliqiangxin (QLQX), a traditional Chinese medicine (TCM) formulation, has shown therapeutic potential in heart failure (HF) through its multifaceted mechanisms. This review article synthesizes preclinical and clinical evidence, highlighting the ability of QLQX to modulate cardiac remodeling, inflammation, fibrosis, and neurohormonal activation. Preclinical studies have revealed that the bioactive components of QLQX target peroxisome proliferator-activated receptor γ, mitochondrial metabolism, and calcium transport. Clinically, QLQX capsule decreases N-terminal pro B-type natriuretic peptide levels and improves functional outcomes in chronic HF. The QUEST trial has indicated diminished cardiovascular mortality and hospitalization in patients with HF and reduced ejection fraction receiving QLQX treatment in addition to standard medication. Challenges include standardization of TCM formulations and mechanistic clarity. Future research should prioritize rigorous trials, comparative studies with conventional therapies, and integration of TCM into evidence-based practice. 

Read more: https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2025.0011

CVIA is available on the ScienceOpen platform and at Cardiovascular Innovations and Applications. Submissions may be made using ScholarOne Manuscripts. There are no author submission or article processing fees. Cardiovascular Innovations and Applications is indexed in the EMBASE, EBSCO, ESCI, OCLC, Primo Central (Ex Libris), Sherpa Romeo, NISC (National Information Services Corporation), DOAJ, Index Copernicus, Research4Life and Ulrich’s web Databases. Follow CVIA on Twitter @CVIA_Journal; or Mingze  

Iokfai Cheang, Gehui Ni and Xinyi Lu et al. Current Understanding and Evidence Regarding Qiliqiangxin (QLQX) in Heart Failure Treatment: From Basic to Clinical Research. CVIA. 2025. Vol. 10(1). DOI: 10.15212/CVIA.2025.0011 

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