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Inflammation in Heart Failure: Mechanisms and Therapeutic Strategies

Announcing a new article publication for journal. Cardiovascular disease remains a leading cause of death and disability worldwide. Heart failure (HF) is the end stage of various cardiovascular diseases. Despite recent advancements in understanding of HF pathogenesis and treatment, the prognosis of patients with HF remains poor. Inflammation is a key player in the development of HF, and its role in the pathogenesis of HF has been extensively studied. Inflammation is associated with elevated HF risk and adverse prognosis. Targeting cardiac inflammation has been suggested as a promising treatment strategy for HF. However, almost all clinical trials on the anti-inflammatory treatment of HF have not indicated improved clinical outcomes, and some have reported deterioration of the condition, possibly because of limited understanding (more…)

A Large-Diameter Thrombus Retrieving Device for Intermediate-Risk Acute Pulmonary Embolism Treatment: A Single-Arm Prospective Clinical Trial

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Globally, acute pulmonary embolism (PE) is the third leading cause of cardiovascular-related deaths after myocardial infarction and stroke. Several studies have reported increased annual incidence of PE and consequently social medical burden. Determining how to treat acute PE more safely and effectively, while decreasing long-term complications, remains an important issue in medicine.

The aim of this study was to report the results of a single-arm clinical trial in (more…)

Quadricuspid Aortic Valve: A Rare Congenital Anomaly Presenting in Adulthood with Severe Aortic Regurgitation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This article discusses the diagnosis of quadricuspid aortic valve (QAV), highlighting a common presentation – detection in midlife following symptoms of severe regurgitation confirmed by transthoracic echocardiography (TTE). The delayed diagnosis underscores how valve dysfunction often emerges later in life.

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Supraventricular Tachycardias in Patients with Congenitally Corrected Transposition of the Great Arteries

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Reentrant supraventricular tachycardias (SVTs) in cc-TGA patients often involve complex reentrant circuits, including twin AV nodes and multiple accessory pathways, frequently associated with Ebstein’s anomaly of the tricuspid valve. Successful management requires a thorough understanding of the unique anatomy and physiology of the conduction system in cc-TGA. Curative interventions like ablation require clear understanding of the anatomical challenges that present in these patients and the potential for multiple and complex reentrant circuits.

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Surgical Treatment of Aortic Annulus Damaged by Infective Endocarditis: A Single-Center Experience

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Infective endocarditis (IE) is a serious infection caused by pathogenic bacteria that travel through the bloodstream and colonize the endocardium, thus resulting in rapid progression, numerous complications, and high mortality. Despite the emergence of new diagnostic and therapeutic strategies, the 1-year mortality rate has not improved and remains at 30%.

Surgical management of IE involving the aortic annulus is critical, because pharmacologic therapy alone is usually insufficient to address the structural damage and hemodynamic instability caused by this severe infection.

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Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface. Atrial fibrillation (AF) is the most prevalent clinically relevant cardiac rhythm condition.Patients with persistent AF have higher levels of C-X-C motif chemokine ligand 8 (CXCL8) than those with paroxysmal AF, thus suggesting a link between long-lasting AF and a low-grade inflammatory response. A newly identified function of C-X-C motif chemokine receptor 2 (CXCR2) is promoting monocyte infiltration of the atria, thus accelerating atrial remodeling and AF after hypertension.

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Cardiac Rehabilitation Knowledge, Attitudes, and Practice among Patients with Heart Failure and Cardiology Healthcare Providers

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac rehabilitation (CR) typically consists of physical activity supplemented with lifestyle modifications, including smoking cessation, adherence to a healthy diet, stress management, medication adherence management, risk factor reduction, psychosocial support, and education. Because CR involves important changes in lifestyle and physical activity, self-management is central to successful CR. Proper knowledge regarding, and attitudes toward, CR are key to effective self-management. Consequently, identifying knowledge gaps, misconceptions, and misunderstandings regarding CR could improve attitudes and practice. (more…)

The Expanding Role of Drug-Coated Balloons and Endothelial Dynamic Strain Assessment in the Treatment of De Novo Atherosclerotic Coronary Artery Disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The potential for drug-coated balloons (DCB) as a primary treatment for de novo atherosclerotic coronary artery disease in larger vessels requires more research. This study highlights the potential for DCB in various sized vessels. The thorough assessment of the target coronary vasculature through computer programs helps to compare coronary arteries and their lesions with the aim of assessing the impact of intervention.

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Role of the E3 Ubiquitin Ligase CBL Family in Cardiovascular Diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The ubiquitin-proteasome system is a fundamental cellular process increasingly considered for diagnostic and therapeutic strategies. Current research on Casitas B-lineage lymphoma (CBL) proteins primarily focuses on understanding its precise roles in the development of different diseases and exploring the feasibility of targeting CBL as a potential therapeutic target by inhibiting or enhancing its function.

On the one hand, blocking the interaction between Casitas B-lineage lymphoma and E2 by small molecules targeting the RING domain of CBL may enhance the activity of CBL-b and c-Cbl, potentially offering therapeutic value in cancer treatment. On the other hand, targeted deletion of the Casitas B-lineage lymphoma gene in specific cells can suppress CBL protein expression levels.

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Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. The authors of this article aimed to identify promising AD biomarkers from high-throughput RNA expressing data.

In the GSE98770 dataset, differentially expressed mRNAs (DE-mRNAs) and microRNAs (DE-microRNAs) were identified through differentially expressed gene analysis and gene set enrichment analysis. The regulatory network between DE-mRNAs and DE-microRNAs was established, and hub genes were identified with Cytoscape.

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