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A Machine Learning Approach to Non-Exercise Prediction of Peak VO 2 in Advanced Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Peak oxygen consumption (VO₂), assessed via cardiopulmonary exercise testing (CPET), is central to heart transplant evaluation in advanced heart failure. However, many patients have limitations that prevent them from completing CPET. This study was aimed at developing machine learning 524 heart transplant candidates (ML) models to estimate peak VO₂ by using non-exercise clinical data who underwent comprehensive clinical, laboratory, echocardiographic, and hemodynamic assessment were retrospectively analyzed.

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Management of Malnutrition in Heart Failure to Optimize Guideline-Directed Medical Therapy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Malnutrition, therapeutic implementation, and clinical outcomes form an intertwined triad in heart failure management. Addressing malnutrition should not be considered an adjunctive measure but rather a critical component of precision cardiovascular care. Systematically integrating nutritional assessment and targeted intervention into HF treatment pathways offers a promising opportunity to improve therapy delivery, patient outcomes, and long-term prognosis. Moving forward, nutritional care deserves recognition as an essential pillar in the comprehensive management of heart failure.

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Efficacy and Safety of a Novel Multi-Channel Vascular Interventional Robotic System: Animal Studies

Announcing a new article publication for Cardiovascular Innovations and Applications journal. The authors of this article have successfully demonstrated the safety and effectiveness of a novel multi-channel vascular interventional robotic system for coronary angiography and stent implantation. Using a randomized trial in animal models, the robotic system achieved 100% procedural success while significantly reducing radiation exposure to operators compared with conventional manual procedures, without increasing risks of infection, bleeding, or organ dysfunction.

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Total Endoscopic Transcatheter Mitral Valve-in-Valve Replacement with Concomitant Left Atrial Appendage Occlusion and Tricuspid Valve Repair

Announcing a new article publication for Cardiovascular Innovations and Applications journal. A 75-year-old man with a history of coronary artery bypass grafting and mitral valve replacement presented with a degenerated mitral bioprosthesis, severe tricuspid regurgitation, and atrial fibrillation. Because of the high surgical risk, a minimally invasive total endoscopic approach was used. Left atrial appendage closure was performed under hypothermic ventricular fibrillation without aortic cross-clamping. Subsequent transcatheter mitral valve-in-valve implantation and concomitant tricuspid valve annuloplasty were successful.

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Hemodynamic Evaluation of an Enhanced External Counterpulsation Strategy for Coronary Heart Disease with a Geometric Multiscale Model

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This research letter highlights a novel approach to optimizing enhanced external counterpulsation (EECP) for patients with coronary heart disease. Using a geometric multiscale model that combines patient-specific three-dimensional coronary artery simulations with systemic circulatory modeling, the study identified wall shear stress (WSS) as a key hemodynamic marker of EECP effectiveness.

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Multi-Omics Exploration of Risk Factors and Pathways Linking Respiratory Conditions and Abdominal Aortic Aneurysm

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This editorial highlights a landmark study that applies an integrative multi-omics framework to uncover a causal connection between chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). Through the combined use of bidirectional Mendelian randomization (MR), tissue-specific expression quantitative trait loci (eQTL) analysis, single-cell RNA sequencing (scRNA-seq), and phenome-wide association studies (PheWAS), the study provides robust genetic and molecular evidence linking the two diseases.

A key discovery is the identification of 48 genes associated with both conditions, including KIF3A, a gene found to inhibit disease activity in both COPD and AAA. The integration of scRNA-seq data allowed localization of relevant genes—such as PLTP, RIF1, and IFI27L2—to immune and stromal cells, providing insights into tissue-specific mechanisms of pathogenesis.

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Genetic and Molecular Relationships Between Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm: Insights from a Multi-Omics Approach

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA) are both severe conditions with complex etiologies and substantial comorbidities. Previous studies have suggested a potential relationship between these diseases, but the underlying genetic and molecular mechanisms remain unclear.

Bidirectional two-sample Mendelian randomization (MR) was used to investigate the causal relationship between COPD and AAA. Expression quantitative trait loci (eQTL) analysis was performed with GTEx V8 summary statistics for aortic and lung tissues. Single-cell sequencing data from GEO datasets were analyzed to identify differentially expressed genes. Finally, a phenome-wide association study (PheWAS) was conducted to explore the broader implications of identified pathogenic genes. (more…)

Nomogram-Based Prediction of Mortality after Cardiac Resynchronization Therapy in Patients with Heart Failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Heart failure (HF) with reduced ejection fraction (HFrEF; LVEF ≤ 35%) affects more than 64 million people globally. The 5-year all-cause mortality exceeds 40% among this population. CRT is a cornerstone treatment for patients with HFrEF with left bundle branch block, prolonged QRS complex duration (ventricular depolarization interval ≥ 150 ms on an electrocardiogram), and New York Heart Association (NYHA) class II–IV symptoms despite optimal medical therapy. However, many patients remain at high risk of mortality post-CRT, particularly those who develop new-onset atrial fibrillation (NOAF), which can disrupt resynchronization and worsen prognosis. Existing prognostic models often do not include NOAF and may lack precision.

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Announcing the Cardiovascular Innovations and Applications (CVIA) 2024 Impact Factor is 1.4

The Co-Editors-in-Chief of Cardiovascular Innovations and Applications (CVIA), Jamie B. Conti, University of Florida, Gainesville, FL, USA, Jianzeng Dong, Beijing Anzhen Hospital, Capital Medical University, Beijing, China and Jun Pu, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, are pleased to announce that the 2024 Journal Impact Factor (JIF) for CVIA is 1.4.

Submissions to Cardiovascular Innovations and Applications (CVIA) can be made using ScholarOne, the online submission and peer review system. Registration and access are available at https://mc04.manuscriptcentral.com/cvia-journal. There are no author submission or article processing fees.

Articles of interest include:

Machine Learning Methods in Real-World Studies of Cardiovascular Disease

The Evolving Role of Transcatheter Tricuspid Valve Edge-to-Edge Repair in Tricuspid Regurgitation

Overview of Postural Orthostatic Tachycardia Syndrome (POTS) for General Cardiologists

Experience in Application of a Three-Dimensional Pulsed Field Ablation System Integrating Mapping and Ablation

Angiography-Based Computational Modeling for In Vivo Assessment of Endothelial Dynamic Strain in Coronary Arteries with De Novo Lesions: Comparison of Treatment Effects of Drug-Coated Balloons Between Small and Large Arteries

Feasibility of an Integrated Digital and Pharmacological Approach Targeting Blood Lipids in Atherosclerotic Cardiovascular Disease Management

Association between Percentage of Neutrophils at Admission and in-Hospital Events in Patients ≥75 Years of Age with Acute Coronary Syndrome

Heart Failure Guideline Directed Medical Therapy: Which One and When?

Overview of Injectable Hydrogels for the Treatment of Myocardial Infarction

Surgical Treatment of Aortic Annulus Damaged by Infective Endocarditis: A Single-Center Experience

Comparative Analysis of Surgical Outcomes in Cardiac Myxoma Resection: Sternotomy Versus Right Mini-Thoracotomy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Despite increasing use of minimally invasive techniques, limited literature has described minithoracotomy for removal of left atrial masses, such as myxomas. This article addresses this gap by analyzing more than a decade of experience at the Cardiovascular Department, Maria Cecilia Hospital, Cotignola, Italy.

Between January 2010 and May 2024, 116 patients underwent either right minithoracotomy or median sternotomy for left atrial myxoma resection. This retrospective study included 96 patients and excluded 20 patients receiving additional procedures. No prior sample size calculation was performed. (more…)

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