Category: 30th GWICC

Protective effect of obeticholic acid on obesity-induced cardiomyopathy

[GW30-e0060] Authors: Chao Li1,2, Shijun Zhang3, Zhibo Gai1,2, Yunlun Li1 1Shandong University of Traditional Chinese Medicine 2Department of Clinical Pharmacology and Toxicology, University Hospital of Zurich 3Shandong University of Traditional Chinese Medicine, Jinan, China OBJECTIVES Obesity is a major contributor to myocardial cell apoptosis, fibrosis and ventricle hypertrophy, and associated with the increased risk of hypertrophic […]

PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative damagein T2DM mice

[GW30-e0056] Authors: Kun Lian, Ling Tao Department of Cardiology, Xijing Hospital, Fourth Military Medical University OBJECTIVES Diabetic patients are more sensitive tomyocardial ischemia-reperfusion (MI/R) injury. Branched-chain amino acids (BCAA) catabolism is defective and mitochondrial phosphatase 2C (PP2Cm) expression is reduced in the diabetic state. However, the role of PP2Cm and BCAA in diabetes with MI/R injury […]

Association of PON1 gene promoter DNA methylation with the risk of clopidogrel poor response in patients with coronary artery disease

[GW30-e0053] Authors: Jia Su, Xiaomin Chen Department of Cardiology, Ningbo No. 1 Hospital, Ningbo, Zhejiang, P.R. China OBJECTIVES The failure of therapeutic response to clopidogrel in platelet inhibition, which is called clopidogrel resistance (CR), is more likely to cause cardiovascular events. We aimed to study the contribution of promoter DNA methylation of paraoxonase 1 (PON1) to […]

Exosomal miRNA-1915-3p, miRNA-4507, and miRNA-3656 serve as clinical diagnostic biomarkers in acute myocardial infarction patients

[GW30-e0052] Authors: Jia Su, Xiaomin Chen Department of Cardiology, Ningbo No. 1 Hospital, Ningbo, Zhejiang, P.R. China OBJECTIVES MicroRNA (miRNA) can be used as predictive biomarkers for cardiovascular diseases, especially for acute myocardial infarction (AMI). However, few reports have focused on the value of exosomal miRNAs in the mechanism of the pathophysiological process from stable coronary […]

Hydronephrosis decreases ACE2 and mas receptor expression in the heart

[GW30-e0051] Authors: Wu Junyan1, Wang Lei2, Zhou Jiansheng3, Zhang Yanling1 1Institute of Cardiovascular Diseases, Taian Maternal and Children’s Hospital, Taian, China 2Department of Pediatric Surgery, Soochow University Affiliated Children’s Hospital, Suzhou, China 3John Curtin School of Medical Research, Australian National University, Australia OBJECTIVES Hydronephrosis is commonly caused by an obstruction of the urine flow from the […]

Echinacoside reduced myocardial apoptosis and improved heart function in heart failure rats induced by isoproterenol via suppressing mitochondrial oxidative stress

[GW30-e0038]Authors: Yajuan Ni, Deng Jie, Liu Xin, Li Qing, Ni Yajuan Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University OBJECTIVES Apoptosis of myocardial cells has been shown to be a critical step provoking heart failure. Studies indicated that mitochondrial oxidative stress and excessive production of mitochondrial ROS in heart failure was tightly linked […]

Effect and potential mechanisms of apolipoprotein A1 on adipogenesis of human adipose-derived mesenchymal stem cells

[GW30-e0030]Authors: Xin Su, Shuai Wang, Daoquan Peng The Second Xiangya Hospital of Central South University OBJECTIVES Obesity is associated with a series of metabolic syndromes. The hallmark of obesity is excessive lipid storage in adipose tissue. As is known, the adipose tissue has such abundant adipose-derived mesenchymal stem cells (AMSCs), which can differentiate into mature adipocytes […]

Apolipoprotein A5 inhibits adipogenesis of human adipose-derived mesenchymal stem cells through modulating CIDEC expression

[GW30-e0029] Authors: Xin Su, Daoquan Peng The Second Xiangya Hospital of Central South University OBJECTIVES Obesity is associated with metabolic syndromes. The hallmark of obesity is excessive lipid storage in adipose tissue. As is known, the adipose tissue has such abundant adipose-derived mesenchymal stem cells (AMSCs), which can differentiate into mature adipocytes by imbalance between energy […]

Age peculiarities of morphological changes in the rats heart at alloxan diabetes

[GW30-e0011] Authors: Yarmolenko Olga, Bumeister Valentyna, Prykhodko Olga, Demikhova Nadiia, Bumeister Lina, Khotyeev Yegor, Sumy State University OBJECTIVES Diabetes mellitus is one of the most common non-communicable diseases. Today, more than 382 million people with diabetes live on the planet. The dynamics of development is increasing every year. Diabetes mellitus is one of the main causes […]