Adverse Outcomes in Non-ST-Elevation Acute Coronary Syndrome: A Cluster Analysis Study

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) have diverse clinical trajectories and form a heterogeneous group. They exhibit differences in clinical and angiographic findings, laboratory parameters including platelet function, and the severity of concomitant pathology. These variations affect their clinical courses and prognosis.

This study examined patients with NSTE-ACS, identified groups with differing laboratory parameters, and performed k-means clustering on clinical, laboratory, and angiographic data.

The study involved 116 patients with NSTE-ACS, primarily with low risk (GRACE 111 ± 25), most of whom were men (64%). The mean age was 64 ± 10 years. Baseline characteristics, including routine laboratory data, were recorded at admission. Platelet reactivity was measured 3–5 days after admission (post-PCI) through detection of p-selectin expression. P-selectin (CD62P) expression on platelet surfaces was measured with a BD FACSCalibur flow cytometer before and after activation with 20 μmol/L ADP, as a percentage of CD62P+ events. The primary outcome was defined as a composite event including all-cause mortality, non-fatal myocardial infarction, or unstable angina recurrence. Follow-up was conducted by telephone 6 months after discharge. Ninety-four clinical and laboratory characteristics were analyzed. Cluster analysis was performed with the k-means method, and a predictive model was developed with logistic regression.

Read full article at https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0044

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D. N. Nedbaeva, V. S. Mikhaleva and G. A. Kukharchik. Adverse Outcomes in Non-ST-Elevation Acute Coronary Syndrome: A Cluster Analysis Study. CVIA. 2024. Vol. 9(1). DOI: 10.15212/CVIA.2024.0044